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Could a daily supplement soothe dry eyes?

NCT ID NCT07453212

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This study tests whether an oral supplement that targets gut bacteria can improve dry eye symptoms in adults with moderate evaporative dry eye disease. Over 8 weeks, 130 participants will take either the supplement or a placebo. The main goal is to see if symptoms, measured by a standard questionnaire, improve more with the supplement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
microbiome-targeted oral food supplement
What this could lead to
If it works, this could offer a simple, non-invasive way to ease dry eye symptoms by targeting gut health.
What could go wrong
This is an early-stage trial with only 130 participants, so results may not apply to everyone. The supplement may not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Incluison criteria: 1. Adults aged 18-65 years. 2. Participants were required to meet all of the following criteria: * Presence of dry eye symptoms, defined as an OSDI-6 summed score ≥4 at baseline. * Objective evidence of tear film homeostasis loss in at least one eye, defined by at least one of the following: A: Non-invasive tear break-up time (NIBUT) \<10 seconds, and/or B: Ocular surface fluorescein staining consistent with DED, defined as: * Corneal and/or conjunctival fluorescein staining graded ≥1 using the Oxford scale, and/or * Lid wiper epitheliopathy graded ≥1 using the Korb grading system 3. Ability to provide written informed consent and comply with study procedures. 4. Willingness to maintain stable use of permitted background measures (e.g., preservative-free artificial tears) and to avoid initiating new probiotics/prebiotics during the trial. Exclusion criteria: 1. Sjögren syndrome or other active systemic autoimmune disease with significant ocular involvement (investigator judgment). 2. Active ocular infection, acute blepharitis flare, or active allergic conjunctivitis requiring escalation of therapy. 3. Ocular surgery (including cataract) or significant ocular trauma within 6 months prior to the Screening Visit. 4. Previous LASIK or any prior corneal surgery at any time. 5. Use of topical cyclosporine, lifitegrast, or topical ocular corticosteroids within 6-8 weeks prior to baseline, or planned initiation during the treatment period. 6. Punctal plugs within 3 months prior to baseline or planned during the study. 7. Use of glaucoma medications or history of glaucoma filtering surgery. 8. Contact lens use within 30 days prior to baseline or planned use during the study. 9. Systemic isotretinoin within 6 months prior to baseline. 10. Systemic antibiotic use within 8 weeks prior to baseline. 11. Eyelid abnormalities affecting lid function (e.g., lagophthalmos, blepharospasm, ectropion, entropion, severe trichiasis). 12. Active thyroid eye disease (thyroid orbitopathy) or clinically significant ocular surface exposure secondary to thyroid dysfunction. 13. Extensive ocular surface scarring or conditions compromising ocular surface integrity, including Stevens-Johnson syndrome, prior chemical burn, recurrent corneal erosions, persistent epithelial defects, or prior severe ocular trauma. 14. Known hypersensitivity to study product ingredients. 15. Any medical or ocular condition that, in the investigator's opinion, would compromise patient safety or study integrity. 16. Pregnancy or breastfeeding (if applicable) or planning pregnancy during the intervention period. 17. Gastrointestinal diseases known to significantly affect digestion, absorption, or intestinal physiology, including but not limited to inflammatory bowel disease, celiac disease, or a history of major gastrointestinal surgery 18. Individuals following restrictive or specialized dietary patterns, including ketogenic, vegan, or similar diets

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Conditions

The condition(s) this trial relates to.

dry eye syndrome Meibomian Gland Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istinye University

    Istanbul, Turkey (Türkiye)

  • Medipol University

    Istanbul, Turkey (Türkiye)

  • T.C. İstanbul Prof. Dr. Cemil Taşcıoğlu Şehir Hastanesi

    Istanbul, 34384, Turkey (Türkiye)

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