Mali allergy study seeks clues in gut and skin germs
NCT ID NCT07051902
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study examines how germs living on and in the body, along with environmental factors like pollution, may influence allergic diseases such as asthma and eczema in people living in Mali. Researchers will collect samples and health information from 288 participants, both with and without allergies, to compare differences. The goal is to identify potential triggers or protective factors, which could inform future prevention or treatment approaches.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could reveal environmental or microbial factors that trigger allergic diseases, pointing toward future prevention or treatment strategies.
- What could go wrong
- This is an observational study, not testing a treatment. It may not find clear differences, and results may not apply to other populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 288 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Study participants will be recruited from the Bamako area
- Ages
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3 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria (Study Group): * Aged ≥3 years. * Able to provide informed consent (for ages ≥18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 years). * Positive Screening questionnaire for asthma or eczema. * Diagnosed with atopic dermatitis or asthma via physician diagnosis and criteria as follows: * Clinical diagnosis of atopic disease, as defined by Hanifin and Rajka criteria, that has been present for ≥3 months before the screening visit. Inclusion Criteria (Healthy Volunteers): * Aged ≥3 years. * Able to provide informed consent (for ages ≥18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 years). * Negative Screening questionnaire for asthma and eczema. * In good general health as evidenced by medical history and not diagnosed with atopic dermatitis or asthma via physician diagnosis. * Failure to meet Hanifin and Rajka criteria and \<3 on GINA guidelines for asthma diagnosis. * No self-reported history of food allergy. Exclusion Criteria: * Use of antibiotics in the 3 months prior to screening. * Current pregnancy or lactation (determined by self-report). * Treatment with an investigational drug within 12 months prior to screening. * Current smoker or tobacco use within 4 months prior to screening. * Current skin infections other than atopic dermatitis (e.g., scabies). * Active diarrhea as defined by three or more loose stools per day (Bristol stool scale score of 6 or 7). * Presence of current bacterial, viral, or fungal infection, with the exception of isolated onchomycosis, which is not exclusionary. * Any other condition or factor that the investigator determines may significantly influence the results of testing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Dermatology Hospital of Bamako
RECRUITINGBamako, Mali
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Pneumology Ward, Point G University Hospital
RECRUITINGBamako, Mali
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