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New eye test could replace painful scrape for infection diagnosis

NCT ID NCT04230811

Diagnosis Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study aimed to see if a soft membrane placed on the eye could diagnose microbial keratitis (a serious eye infection) better and more comfortably than the standard scrape test. Researchers planned to compare the two methods in adults with new corneal infections. However, the study was withdrawn before any patients were enrolled, so no conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Corneal impression membrane (a soft membrane placed on the eye to collect germs)
What this could lead to
If successful, this could offer a less painful and more accurate way to diagnose serious eye infections, potentially replacing the current scrape method.
What could go wrong
The study was withdrawn before any participants were enrolled, so no results are available. The new test may not be as sensitive or safe as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Started

Feb 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients attending the Princess Alexandra Eye Pavilion in Edinburgh, who are given a clinical diagnosis of microbial keratitis in one or both eyes

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients 18 years old or older * Appearances typical of a new bacterial, fungal or acanthamoeba infection of the cornea, in one or both eyes * Able to give informed consent Exclusion Criteria: * Patients who don't give consent * Patients who would not normally have a corneal scrape as part of routine care. This includes patients with viral rather than bacterial corneal infection, such as herpetic keratitis. * Patients with corneal perforation or descemetocele

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Conditions

The condition(s) this trial relates to.

corneal infection corneal ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Corneal ulcer (diagnosis)

Contacts and locations

Locations

  • Royal Infirmary of Edinburgh

    Edinburgh, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.