Can Micro-Holes in bone shorten orthodontic treatment?
NCT ID NCT07761065
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial investigates whether micro-osteoperforations—tiny, controlled holes in the jawbone—can accelerate the movement of upper back teeth downward to correct an anterior open bite. Thirty patients with open bite will receive either this procedure plus standard orthodontic intrusion or standard intrusion alone. The study measures how quickly teeth move, changes in bone and airway, and any side effects like root resorption, to see if this technique offers a faster, safer path to bite correction.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Micro-osteoperforation (a procedure using tiny, controlled bone perforations to accelerate tooth movement)
- What this could lead to
- If effective, this technique could shorten orthodontic treatment time for open bite patients, reducing the need for lengthy or invasive procedures.
- What could go wrong
- This is a small, early-stage study (30 participants) and results may not apply broadly. The procedure carries typical risks of minor discomfort, swelling, or infection, and its benefit over standard care is not yet proven.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Apr 2015
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 30 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Clinical anterior open bite involving the incisors and canines ranging from -3 mm to -8 mm * Skeletal open bite confirmed by pretreatment cephalometric angular and linear measurements. * Maxillary posterior vertical dentoalveolar excess guided by the analysis of Burstone et al. * Normal incisor display at rest and during smile. * Non-growing postpubertal adolescent and adult patients with CVM 6 according to Baccetti et al. * Full set of permanent dentition regardless of third molars. * Good oral hygiene. Exclusion Criteria: * Skeletal Class III cases. * Patients suffering from any systemic diseases or congenital anomalies affecting bone. * Patients with previous orthodontic treatment.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ain Shams University
Cairo, Abbasia, 11566, Egypt
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