Drilling tiny holes in jaw may cut aligner time in half
NCT ID NCT05492773
First seen Jun 26, 2026 · Last updated Sep 17, 2026 · Updated 2 times
Summary
This study tests whether making tiny holes in the jaw bone (micro-osteoperforations) can help straighten crowded lower front teeth faster when using clear aligners. Thirty adults with moderate crowding will be split into two groups: one gets aligners plus the bone-drilling procedure, the other gets aligners alone. Researchers will measure how quickly teeth move and how much pain patients feel.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Micro-osteoperforations (tiny holes drilled in the jaw bone to accelerate tooth movement)
- What this could lead to
- If it works, this could shorten the time people need to wear clear aligners for mild crowding, making orthodontic treatment faster and more convenient.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The procedure involves minor surgery and may cause temporary pain or swelling.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 26 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Completion of permanent dentition (except third molars) * Moderate crowding (4-6 mm according to Little's index) * Absence of medications intake that interferes with pain perception for at least one week before the beginning of the treatment * Number of aligners ≥ 8 aligners. Exclusion Criteria: * • Systematic diseases that could affect bone and tooth movement and no contraindication avoid oral surgery * Medical conditions that affect tooth movement (Corticosteroid, NSAIDs) * Patients had previous orthodontic treatments * Poor oral hygiene or concurrent periodontal disease
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hama University
RECRUITINGHama, Syria
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