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New hope for Hard-to-Treat cancers: experimental drug enters human testing

NCT ID NCT03460977

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 25, 2026 · Updated 8 times

Summary

This early-phase study tests an experimental drug called mevrometostat in adults with certain advanced cancers that have stopped responding to standard treatments. The study is currently enrolling men with castration-resistant prostate cancer. Participants receive the drug by mouth, sometimes combined with another drug (enzalutamide), to see if it is safe and whether it can slow cancer growth. The goal is to find the best dose and understand side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 453 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2018

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Part 1 and Part 2 (Closed for enrollment). Part 3 Key Inclusion Criteria: * Histological or cytological diagnosis of castration resistant prostate cancer. * Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-2 with expected life expectancy of at least 6 months. * Adequate bone marrow, renal, and liver function Part 3 Key Exclusion Criteria: * Prior irradiation to \>25% of the bone marrow. * QTcF interval \>480 msec at screening. * Hypertension that cannot be controlled by medications (\>150/90 mmHg despite optimal medical therapy). * Known or suspected hypersensitivity to PF 06821497 or any components or enzalutamide (CRPC) * Active inflammatory gastrointestinal disease, chronic diarrhea, known diverticular disease or previous gastric resection or lap band surgery. * Current use or anticipated need for food or drugs that are known strong and moderate CYP3A4/5 inducers or inhibitors * Prior enzalutamide within the last 4 weeks * DDI SUBSTUDY: * history of CHF or evidence of ventricular dysfunction * fructose intolerance * coadministration of CYP3A4 substrates

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma follicular lymphoma metastatic prostate carcinoma Recurrence small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Follicular lymphoma (FL) Metastatic castration-resistant prostate cancer (MCRPC) Small cell lung cancer ( SCLC )

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    26 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Arizona Urology Specialists, PLLC

    TERMINATED

    Tucson, Arizona, 85741, United States

  • Banner-University Medical Center Tucson

    ACTIVE_NOT_RECRUITING

    Tucson, Arizona, 85719, United States

  • Brigham and Women's Hospital

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02115, United States

  • Budgetary Healthcare Institution of Omsk region "Clinical Oncological Dispensary"

    TERMINATED

    Omsk, 644013, Russia

  • Carolina Urologic Research Center

    RECRUITING

    Myrtle Beach, South Carolina, 29572, United States

  • Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.

    RECRUITING

    Krakow, 30-348, Poland

  • Centrum Medyczne MEDYK

    ACTIVE_NOT_RECRUITING

    Rzeszów, 35-326, Poland

  • Chungnam national university hospital

    ACTIVE_NOT_RECRUITING

    Daejeon, Taejǒn-kwangyǒkshi, 35015, South Korea

  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

    ACTIVE_NOT_RECRUITING

    Duarte, California, 91010, United States

  • City of Hope Investigational Drug Services (IDS)

    ACTIVE_NOT_RECRUITING

    Duarte, California, 91010, United States

  • Consorcio Hospitalario Provincial de Castellon

    ACTIVE_NOT_RECRUITING

    Castellon, Castellon, 12002, Spain

  • Dana Farber Cancer Institute

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Dana Farber Cancer Institute- Chestnut Hill

    ACTIVE_NOT_RECRUITING

    Newton, Massachusetts, 02459, United States

  • Ewha Womans University Mokdong Hospital

    ACTIVE_NOT_RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 07985, South Korea

  • Federal State Budgetary Institution National Medical Research Center for Oncology n.a. N.N.

    TERMINATED

    Saint Petersburg, 197758, Russia

  • Federal State Budgetary Institution National Medical Research Center n.a. V.A. Almazov

    TERMINATED

    Saint Petersburg, 197341, Russia

  • Fred Hutchinson Cancer Center

    ACTIVE_NOT_RECRUITING

    Seattle, Washington, 98109, United States

  • Fred Hutchinson Cancer Center Alliance Peninsula

    ACTIVE_NOT_RECRUITING

    Poulsbo, Washington, 98370, United States

  • H.U. Fundación Jiménez Díaz

    RECRUITING

    Madrid, 28040, Spain

  • Hackensack University Medical Center

    ACTIVE_NOT_RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Hospital Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Quironsalud Barcelona

    RECRUITING

    Barcelona, 08023, Spain

  • Hospital Quironsalud Madrid

    RECRUITING

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitari i Politecnic La Fe

    ACTIVE_NOT_RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario 12 De Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario HM Sanchinarro

    RECRUITING

    Madrid, 28050, Spain

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, 29010, Spain

  • Hunan Cancer Hospital

    RECRUITING

    Changsha, Hunan, 410013, China

  • In-Vivo Sp. z o.o. In-vivo Bydgoszcz

    NOT_YET_RECRUITING

    Bydgoszcz, 85-048, Poland

  • Institut Català d´Oncología (ICO)-H. Durán i Reynals

    ACTIVE_NOT_RECRUITING

    L'Hospitalet de Llobregat, Barecelona, 08908, Spain

  • John Theurer Cancer Center at Hackensack University Medical Center

    ACTIVE_NOT_RECRUITING

    Hackensack, New Jersey, 07601, United States

  • LLC "Neyro-klinika"

    ACTIVE_NOT_RECRUITING

    Moscow, 117186, Russia

  • Maryland Oncology Hematology, P.A.

    TERMINATED

    Rockville, Maryland, 20850, United States

  • Moscow GBUZ "City clinical hospital n. a. S.P. Botkina" of Moscow health department

    TERMINATED

    Moscow, 125284, Russia

  • NEXT Dallas

    RECRUITING

    Irving, Texas, 75039, United States

  • NEXT Oncology

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    RECRUITING

    Nanjing, Jiangsu, 210008, China

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie

    ACTIVE_NOT_RECRUITING

    Warsaw, 02-781, Poland

  • National Cancer Center Hospital East

    ACTIVE_NOT_RECRUITING

    Kashiwa, Chiba, 277-8577, Japan

  • Norton Cancer Institute - Downtown

    ACTIVE_NOT_RECRUITING

    Louisville, Kentucky, 40202, United States

  • Norton Cancer Institute, Norton Healthcare Pavilion

    ACTIVE_NOT_RECRUITING

    Louisville, Kentucky, 40202, United States

  • Norton Hospital

    ACTIVE_NOT_RECRUITING

    Louisville, Kentucky, 40202, United States

  • Norwalk Hospital

    ACTIVE_NOT_RECRUITING

    Norwalk, Connecticut, 06856, United States

  • OU Health University of Oklahoma Medical Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Olympic Medical Center

    ACTIVE_NOT_RECRUITING

    Port Angeles, Washington, 98362, United States

  • Oncology Hematology West, PC dba Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68130, United States

  • Pacific Cancer Medical Center INC

    ACTIVE_NOT_RECRUITING

    Anaheim, California, 92801, United States

  • Parkway Surgery Center

    RECRUITING

    Myrtle Beach, South Carolina, 29572, United States

  • Private Medical Institution "Euromedservice"

    ACTIVE_NOT_RECRUITING

    Pushkin, Sankt-Peterburg, 196603, Russia

  • SBHI of Moscow City Clinical Hospital

    TERMINATED

    Moscow, 129301, Russia

  • SCRI Oncology Partners

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Saint Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary"

    TERMINATED

    Saint Petersburg, 198255, Russia

  • Sarah Cannon Research Institute - Pharmacy

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam, Kyǒnggi-do, 13620, South Korea

  • Seoul National University Hospital

    ACTIVE_NOT_RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    ACTIVE_NOT_RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea

  • Specialized Hospital for Active Treatment of Oncology - Haskovo

    TERMINATED

    Haskovo, 6300, Bulgaria

  • State Budgetary Healthcare Institution of the Yaroslavl Region

    TERMINATED

    Yaroslavl, 150054, Russia

  • Stephenson Cancer Center (chemo location)

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie

    ACTIVE_NOT_RECRUITING

    Koszalin, 75-581, Poland

  • Texas Oncology - Austin Midtown

    TERMINATED

    Austin, Texas, 78705, United States

  • The First Affiliated Hospital of Guangzhou Medical University

    ACTIVE_NOT_RECRUITING

    Guangzhou, Guangdong, 510120, China

  • The First Affiliated Hospital of Wenzhou Medical University

    ACTIVE_NOT_RECRUITING

    Wenzhou, Zhejiang, 325000, China

  • The University of Arizona Cancer Center

    ACTIVE_NOT_RECRUITING

    Tucson, Arizona, 85724, United States

  • The University of Arizona Cancer Center-North Campus

    ACTIVE_NOT_RECRUITING

    Tucson, Arizona, 85719, United States

  • The University of Kansas Cancer Center

    ACTIVE_NOT_RECRUITING

    Westwood, Kansas, 66205, United States

  • The University of Kansas Cancer Center - Indian Creek Campus

    ACTIVE_NOT_RECRUITING

    Overland Park, Kansas, 66211, United States

  • The University of Kansas Cancer Center, Investigational Drug Services

    ACTIVE_NOT_RECRUITING

    Fairway, Kansas, 66205, United States

  • The University of Kansas Clinical Research Center

    ACTIVE_NOT_RECRUITING

    Fairway, Kansas, 66205, United States

  • The University of Kansas Hospital

    ACTIVE_NOT_RECRUITING

    Kansas City, Kansas, 66160, United States

  • The University of Kansas Medical Center Medical Office Building

    ACTIVE_NOT_RECRUITING

    Kansas City, Kansas, 66160, United States

  • US Oncology Investigational Product Center (IPC)

    TERMINATED

    Irving, Texas, 75063, United States

  • US Oncology Investigational Products Center

    TERMINATED

    Irving, Texas, 75063, United States

  • UT Southwestern Medical Center

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75390, United States

  • UT Southwestern University Hospital - William P. Clements, Jr

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75390, United States

  • UT Southwestern University Hospital - Zale Lipshy

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75390, United States

  • University of Texas Southwestern Medical Center - Simmons Cancer Center

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75390, United States

  • University of Washington Medical Center

    ACTIVE_NOT_RECRUITING

    Seattle, Washington, 98109, United States

  • Virginia Cancer Specialists, PC

    ACTIVE_NOT_RECRUITING

    Fairfax, Virginia, 22031, United States

  • West China Hospital, Sichuan University

    RECRUITING

    Chengdu, Sichuan, 610041, China

  • Zhongda Hospital Southeast University

    RECRUITING

    Nanjing, Jiangsu, 210009, China

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