New hope for tough cancers: experimental drug mevrometostat enters human trials

NCT ID NCT03460977

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 30 times

Summary

This early-stage study tests an experimental drug called mevrometostat in adults with advanced prostate cancer, small cell lung cancer, or follicular lymphoma that has stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow disease progression. Participants take the drug by mouth, and some also receive another drug (enzalutamide) to boost the effect.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Arizona Urology Specialists, PLLC
TERMINATED

Tucson, Arizona, 85741, United States
Banner-University Medical Center Tucson
ACTIVE_NOT_RECRUITING

Tucson, Arizona, 85719, United States
Brigham and Women's Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02115, United States
Budgetary Healthcare Institution of Omsk region "Clinical Oncological Dispensary"
TERMINATED

Omsk, 644013, Russia
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Centrum Medyczne MEDYK
ACTIVE_NOT_RECRUITING

Rzeszów, 35-326, Poland
Chungnam national university hospital
ACTIVE_NOT_RECRUITING

Daejeon, Taejǒn-kwangyǒkshi, 35015, South Korea
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
City of Hope Investigational Drug Services (IDS)
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
Consorcio Hospitalario Provincial de Castellon
ACTIVE_NOT_RECRUITING

Castellon, Castellon, 12002, Spain
Dana Farber Cancer Institute
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Dana Farber Cancer Institute- Chestnut Hill
ACTIVE_NOT_RECRUITING

Newton, Massachusetts, 02459, United States
Ewha Womans University Mokdong Hospital
ACTIVE_NOT_RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 07985, South Korea
Federal State Budgetary Institution National Medical Research Center for Oncology n.a. N.N.
TERMINATED

Saint Petersburg, 197758, Russia
Federal State Budgetary Institution National Medical Research Center n.a. V.A. Almazov
TERMINATED

Saint Petersburg, 197341, Russia
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fred Hutchinson Cancer Center Alliance Peninsula
RECRUITING

Poulsbo, Washington, 98370, United States
H.U. Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hackensack University Medical Center
ACTIVE_NOT_RECRUITING

Hackensack, New Jersey, 07601, United States
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Quironsalud Barcelona
RECRUITING

Barcelona, 08023, Spain
Hospital Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 De Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410013, China
Institut Català d´Oncología (ICO)-H. Durán i Reynals
RECRUITING

L'Hospitalet de Llobregat, Barecelona, 08908, Spain
John Theurer Cancer Center at Hackensack University Medical Center
ACTIVE_NOT_RECRUITING

Hackensack, New Jersey, 07601, United States
LLC "Neyro-klinika"
ACTIVE_NOT_RECRUITING

Moscow, 117186, Russia
Maryland Oncology Hematology, P.A.
TERMINATED

Rockville, Maryland, 20850, United States
Moscow GBUZ "City clinical hospital n. a. S.P. Botkina" of Moscow health department
TERMINATED

Moscow, 125284, Russia
NEXT Oncology
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
NEXT Oncology
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78240, United States
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
RECRUITING

Nanjing, Jiangsu, 210008, China
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
ACTIVE_NOT_RECRUITING

Warsaw, 02-781, Poland
National Cancer Center Hospital East
ACTIVE_NOT_RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Norton Cancer Institute Pharmacy
ACTIVE_NOT_RECRUITING

Louisville, Kentucky, 40202, United States
Norton Cancer Institute Pharmacy, Downtown Pharmacy
ACTIVE_NOT_RECRUITING

Louisville, Kentucky, 40202, United States
Norton Cancer Institute, Norton Healthcare Pavilion
ACTIVE_NOT_RECRUITING

Louisville, Kentucky, 40202, United States
Norton Hospital
ACTIVE_NOT_RECRUITING

Louisville, Kentucky, 40202, United States
Norwalk Hospital
ACTIVE_NOT_RECRUITING

Norwalk, Connecticut, 06856, United States
OU Health University of Oklahoma Medical Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Olympic Medical Center
RECRUITING

Port Angeles, Washington, 98362, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Pacific Cancer Medical Center INC
ACTIVE_NOT_RECRUITING

Anaheim, California, 92801, United States
Parkway Surgery Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Private Medical Institution "Euromedservice"
ACTIVE_NOT_RECRUITING

Pushkin, Sankt-Peterburg, 196603, Russia
SBHI of Moscow City Clinical Hospital
TERMINATED

Moscow, 129301, Russia
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Saint Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary"
TERMINATED

Saint Petersburg, 198255, Russia
Sarah Cannon Research Institute - Pharmacy
RECRUITING

Nashville, Tennessee, 37203, United States
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea
Seoul National University Hospital
ACTIVE_NOT_RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Severance Hospital, Yonsei University Health System
TERMINATED

Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
Specialized Hospital for Active Treatment of Oncology - Haskovo
TERMINATED

Haskovo, 6300, Bulgaria
State Budgetary Healthcare Institution of the Yaroslavl Region
TERMINATED

Yaroslavl, 150054, Russia
Stephenson Cancer Center (chemo location)
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie
ACTIVE_NOT_RECRUITING

Koszalin, 75-581, Poland
Texas Oncology - Austin Midtown
TERMINATED

Austin, Texas, 78705, United States
The First Affiliated Hospital of Guangzhou Medical University
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 510120, China
The First Affiliated Hospital of Wenzhou Medical University
ACTIVE_NOT_RECRUITING

Wenzhou, Zhejiang, 325000, China
The University of Arizona Cancer Center
ACTIVE_NOT_RECRUITING

Tucson, Arizona, 85724, United States
The University of Arizona Cancer Center-North Campus
ACTIVE_NOT_RECRUITING

Tucson, Arizona, 85719, United States
The University of Kansas Cancer Center
ACTIVE_NOT_RECRUITING

Westwood, Kansas, 66205, United States
The University of Kansas Cancer Center - Indian Creek Campus
ACTIVE_NOT_RECRUITING

Overland Park, Kansas, 66211, United States
The University of Kansas Cancer Center, Investigational Drug Services
ACTIVE_NOT_RECRUITING

Fairway, Kansas, 66205, United States
The University of Kansas Clinical Research Center
ACTIVE_NOT_RECRUITING

Fairway, Kansas, 66205, United States
The University of Kansas Hospital
ACTIVE_NOT_RECRUITING

Kansas City, Kansas, 66160, United States
The University of Kansas Medical Center Medical Office Building
ACTIVE_NOT_RECRUITING

Kansas City, Kansas, 66160, United States
US Oncology Investigational Product Center (IPC)
TERMINATED

Irving, Texas, 75063, United States
US Oncology Investigational Products Center
TERMINATED

Irving, Texas, 75063, United States
UT Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
UT Southwestern University Hospital - William P. Clements, Jr
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
UT Southwestern University Hospital - Zale Lipshy
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Texas Southwestern Medical Center - Simmons Cancer Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98109, United States
Virginia Cancer Specialists, PC
ACTIVE_NOT_RECRUITING

Fairfax, Virginia, 22031, United States
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Zhongda Hospital Southeast University
RECRUITING

Nanjing, Jiangsu, 210009, China

Conditions

Explore the condition pages connected to this study.

FOLLICULAR LYMPHOMA (FL) METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) SMALL CELL LUNG CANCER (SCLC) SMALL CELL LUNG CANCER (SCLC)