Could a common arthritis drug ease knee pain? new trial investigates
NCT ID NCT07161336
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 29 times
Summary
This phase 2 trial tests whether methotrexate, a drug used for rheumatoid arthritis, can reduce pain and improve function in people with knee osteoarthritis who also have joint inflammation (synovitis) seen on ultrasound. Seventy adults aged 40-70 will receive either methotrexate or a placebo for 6 months, and researchers will measure changes in pain, stiffness, and daily activities. The goal is to see if targeting inflammation can offer relief for a condition with limited treatment options.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
RECRUITINGDhaka, Dhaka Division, Bangladesh
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methotrexate
What this could lead to
If it works, this could point toward a new treatment option for knee osteoarthritis patients with joint inflammation, potentially easing pain and improving mobility.
What could go wrong
This is a small, early-phase trial with only 70 participants, so results may not apply to everyone. Methotrexate can cause side effects like nausea or liver issues, and it may not prove more effective than placebo.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.