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Toothache breakthrough: blood test may predict need for root canal

NCT ID NCT07452614

Knowledge-focused Sponsor: Abeer Ghalib Abdul-khaliq Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether substances in the blood from a decayed tooth can predict if a tooth-saving procedure called vital pulp treatment will succeed. Researchers will collect a small blood sample from the tooth during treatment and check for specific metabolic markers. They will follow 60 patients for 12 months to see if the markers can tell which teeth heal well and which need more intensive treatment like a root canal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test that helps dentists decide the best treatment for a painful tooth, avoiding unnecessary root canals.
What could go wrong
This is a small, early-stage study with only 60 participants. The biomarkers may not reliably predict outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age range of 16-50 years. 2. Pulp exposure during treatment of deep caries. 3. Absence of periodontitis or systemic disease. 4. Only one or two proximal surfaces lost with remaining walls \> 2 mm; and 5. Good compliance and signed informed consent forms. Exclusion Criteria: 1. Patients who meet any of the following criteria will be excluded: 2. Teeth with unrestorable large defects or the need for RCT for aesthetic reasons; 3. Teeth with a negative response to cold testing 4. Current pregnancy or breastfeeding; 5. Poor compliance or inability to complete the trial. 6. The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study. 7. Inadequate blood sample collection after pulpal exposure.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder pulpitis Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irreversible pulpitis (toothache) Pulp disease, dental Pulpitis Reversible pulpitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • College of dentistry\ University of Baghdad

    RECRUITING

    Baghdad, 964, Iraq

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