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Cooling gel may soothe sore muscles after a marathon, study finds

NCT ID NCT07565246

Symptom relief Sponsor: Reckitt Benckiser Healthcare (UK) Limited Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a menthol gel (Biofreeze) helps reduce muscle soreness in adults running the 2025 Chicago Marathon. 367 runners used the gel during or after the race and reported their pain levels. Researchers compared pain scores before and after applying the gel to see if it provides quick relief and a cooling sensation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
menthol (topical gel, Biofreeze)
What this could lead to
If it works, this could show that menthol gel is a simple, over-the-counter option for easing muscle soreness after intense exercise.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by people's expectations. It only looked at marathon runners, so findings may not apply to other types of pain or activity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

367 people

The number who actually took part.

Started

Oct 2025

Finished

Oct 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will recruit runners over 18 years old, participating in the 2025 Chicago Marathon, capable of providing documented informed consent, who are not employees of Sponsor or the vendor collecting data.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participant has provided documented informed consent. 2. Participant aged 18 years and above. 3. Participant is entrant into the Chicago marathon 2025. 4. Participant has self-selected to use topically applied menthol during the race or during immediate recovery. 5. Comprehension of and able to read English. Exclusion Criteria: 1\. Employee of Sponsor or Agency/ vendor collecting the data

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Conditions

The condition(s) this trial relates to.

Myalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Muscle soreness

Contacts and locations

Locations

  • Curion Strategic Product Insights

    Deerfield, Illinois, 60015, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.