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Period pain? root canal recovery worse during certain cycle phases

NCT ID NCT07291518

Knowledge-focused Sponsor: Ahter Sanal Cikman Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether the menstrual cycle affects pain after a root canal. 99 people (72 women and 27 men) took part. Women in the menstrual and secretory phases reported more pain than men, while those in the proliferative phase had similar pain levels. The results suggest that cycle timing may influence short-term pain after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

99 people

The number who actually took part.

Started

Sep 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of 99 adult patients (72 females and 27 males), aged 18-50 years, requiring endodontic treatment for asymptomatic necrotic mandibular first or second molars. Female participants have regular menstrual cycles and are categorized into menstrual, proliferative, or secretory phases. Patients with systemic diseases, smoking habits, preoperative pain, parafunctional habits, teeth requiring prosthetic restoration, immature teeth, periodontal probing depth greater than 3 mm, or irregular menstrual cycles are excluded. All participants provided written informed consent prior to enrollment.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-50 years * Male or female patients requiring endodontic treatment of asymptomatic * Necrotic mandibular first or second molars * Female patients with regular menstrual cycles * Patients who have not taken analgesics in the last 3 days * Patients willing to provide written informed consent Exclusion Criteria: * Smoking habit * Systemic diseases or use of systemic drugs * Parafunctional habits such as bruxism * Preoperative pain * Teeth requiring prosthetic restoration * Teeth with external or internal resorption * Immature teeth * Periodontal probing depth \> 3 mm * Pregnant women * Women with irregular menstrual cycles * Patients who refuse to participate

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Root canal treatment

Contacts and locations

Locations

  • Recep Tayyip Erdoğan Univercity

    Rize, 53020, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.