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Women's hormones and muscle growth: new study aims to fill research gap

NCT ID NCT07258576

Knowledge-focused Sponsor: University of Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how natural menstrual cycles and oral contraceptive use affect muscle protein synthesis after resistance training. Twenty recreationally active women will consume protein drinks and undergo muscle biopsies to measure protein building. The goal is to understand if hormone fluctuations change how muscles respond to exercise and protein, which could lead to better fitness advice for women.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Protein Beverage
What this could lead to
If successful, this study could lead to better training and nutrition recommendations tailored to women's hormonal cycles.
What could go wrong
This is a small, early-stage observational study with only 20 participants, so results may not apply broadly. It does not test a treatment or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 18-40 years * BMI between 18.5-29.9 kg/m2 (non-obese) * Recreationally active (resistance train minimum twice a week) * Using monophasic or triphasic oral contraceptives for \>1 year (for oral contraceptive users) * Have regular menstrual cycles (21-35 days) for the past 3 months and discontinued any hormonal contraceptive use for at least 6 months (non-oral contraceptive users) * Must meet a progesterone sufficiency test (non-oral contraceptive users) Exclusion Criteria: * Mid-luteal progesterone levels \<16umol * Chronic disease diagnosis (cardiovascular, thyroid, diabetes) * Current or recent remission of cancer * Regular use of non-steroidal anti-inflammatory drugs (NSAIDs; except low-dose aspirin), anticoagulants * Use of prescription drugs that would impact muscle protein synthesis, e.g. Statins, Lithium, ADHD medication. * Insertion of intrauterine device (IUD) - exception: copper * Use of emergency contraception in the last 3 months (e.g. Plan B) * Severe food allergies (e.g. soy, nuts) * Smoking, use of performance enhancing drugs (growth hormones, testosterone)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Female sex hormones Menstrual cycle Oral contraceptives Protein metabolism

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Goldring Center for High Performance Sport

    RECRUITING

    Toronto, Ontario, M5S 2C9, Canada

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