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Scientists probe menopause Hormones' hidden impact on nerves

NCT ID NCT07420218

Knowledge-focused Sponsor: University of Delaware Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how the hormones estradiol and FSH, which change during menopause, affect the sympathetic nervous system—the part that controls your 'fight or flight' response. Researchers will give 80 perimenopausal women a medication to temporarily control these hormones, then measure nerve activity using MRI and other tests. The goal is to better understand how these hormonal shifts might influence health, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Estradiol patch and GnRH antagonist
What this could lead to
If successful, this could clarify how menopausal hormone changes influence stress responses and blood pressure regulation, potentially guiding future treatments for heart health in menopause.
What could go wrong
This is a small, early-phase mechanistic study, not a treatment trial. Results may not translate into direct clinical benefits or apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 58 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Perimenopausal (based on changes in menstrual cycle) * Ages 40-58 years Exclusion Criteria: * History of CVD, blood clots, stroke * History of Cancer * History of Liver or Kidney disease * History of Neurological disease * Diabetes * BMI\>35kg/m2 * Pregnant, planning on becoming pregnant, or breast feeding * Allergy to Latex * Use of Tobacco * Hysterectomy * Blood pressure \>140/90 mmHg * Current or prior use of hormone replacement therapy (within 3 mo)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perimenopausal women

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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