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Placenta may be a melatonin factory in pregnancy, tiny study hints

NCT ID NCT03609086

Knowledge-focused Sponsor: University of Aberdeen Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether the placenta produces the high levels of melatonin seen in late pregnancy. Researchers measured melatonin in the blood of 15 women before and after a planned C-section, and in the umbilical cord and placenta. The goal was to understand where the melatonin comes from and if it could one day be used to spot pregnancy problems like pre-eclampsia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help understand why melatonin rises in pregnancy and whether it can be used as a marker for pregnancy complications.
What could go wrong
This is a very small pilot study with only 15 women, so results may not apply to all pregnancies. It only measures levels, not treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15 people

The number who actually took part.

Started

Jun 2018

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy pregnant women scheduled for elective Caesarean section

Ages

16 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled for elective caesarian section * Singleton pregnancy * Aged 16-45 * Taking no regular medication other than pregnancy related vitamins or supplements Exclusion Criteria: * Pregnancy non-viable * Twins or higher multiple pregnancies * Outside age range * Diabetes or pre-existing hypertension, chronic kidney disease or autoimmune disorders

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pregnancy

Contacts and locations

Locations

  • Aberdeen Maternity Hospital

    Ellon, Lowland Scotland, AB25 2ZB, United Kingdom

  • University of Aberdeen/NHS Grampian

    Aberdeen, If Already Stated Select NOT Listed, AB25 2ZD, United Kingdom

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