Melatonin may calm nerves before sinus surgery – study finds optimal dose
NCT ID NCT07550751
First seen Apr 29, 2026 · Last updated Jun 23, 2026 · Updated 10 times
Summary
This study tested different doses of melatonin (3, 5, and 10 mg) compared to a placebo in 160 adults undergoing sinus surgery. The goal was to see which dose best reduces anxiety and pain while keeping heart rate and blood pressure stable. Results could help doctors choose the right melatonin dose for a smoother surgical experience.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aswan university hospitals
Aswān, Egypt
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Melatonin
What this could lead to
If successful, this could identify the best melatonin dose to reduce anxiety and improve comfort before sinus surgery.
What could go wrong
This is a small, completed Phase 4 trial. Melatonin is generally safe, but its effectiveness for sedation may vary and may not replace standard sedatives.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.