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Face-Off: natural blood injection vs drug for stubborn melasma

NCT ID NCT07540702

Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting platelet-rich fibrin (made from your own blood) works better than tranexamic acid for treating facial melasma, a common skin condition causing dark patches. Twenty-one women with melasma will receive one treatment on each side of their face. The goal is to see which reduces pigmentation more safely over five sessions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich fibrin (i-PRF) and tranexamic acid
What this could lead to
If i-PRF works better or as well as tranexamic acid, it could offer a new, natural treatment option for melasma with fewer side effects.
What could go wrong
This is a small, early-stage study with only 21 participants. Results may not apply to everyone, and both treatments may cause temporary redness, swelling, or bruising.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of bilateral symmetrical facial melasma (epidermal or mixed type) * Female participants aged 18 to 50 years * Fitzpatrick skin types III to IV * Mild to moderate facial melasma * No melasma-specific treatment within the previous 4 weeks * No facial procedures, including peeling, laser resurfacing, or microneedling, within the previous 3 months * Willing and able to provide written informed consent and comply with study procedures Exclusion Criteria: * Pregnancy or lactation * Bleeding or coagulation disorders * Use of anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), or hormonal contraception * Active skin infection or facial inflammation * History of keloids or Koebner-prone conditions, such as psoriasis or vitiligo * Uncontrolled systemic disease, such as diabetes mellitus or autoimmune disease

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Conditions

The condition(s) this trial relates to.

Melanosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial melasma Melasma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kasr El Aini Hospital

    RECRUITING

    Cairo, Cairo Governorate, 11555, Egypt

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