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Less surgery may be just as effective for advanced melanoma after immunotherapy

NCT ID NCT07049276

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 26 times

Summary

This study tests whether removing only the largest affected lymph node (index node) is as good as removing all lymph nodes in the area for stage III melanoma. After 6 weeks of standard immunotherapy, 1500 participants will be randomly assigned to one of the two surgeries. The goal is to see if the less extensive surgery leads to fewer side effects like swelling and wound problems, while still keeping the cancer from coming back for at least 2 years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Calvary Mater Newcastle

    RECRUITING

    Newcastle, New South Wales, 2298, Australia

    Contact Phone: •••-•••-••••

  • Cedars-Sinai Medical Centre

    NOT_YET_RECRUITING

    Los Angeles, California, 90025, United States

    Contact

  • Fiona Stanley Hospital

    NOT_YET_RECRUITING

    Murdoch, Western Australia, 6961, Australia

    Contact Phone: •••-•••-••••

  • Melanoma Institute Australia

    RECRUITING

    Wollstonecraft, New South Wales, 2065, Australia

    Contact

  • San Maria della Misericordia Hospital

    NOT_YET_RECRUITING

    Perugia, Italy

    Contact

  • Sunnybrook Health Sciences Centre

    NOT_YET_RECRUITING

    Toronto, Ontario, Canada

    Contact

  • The Royal Marsden

    NOT_YET_RECRUITING

    London, United Kingdom

    Contact

Conditions

Explore the condition pages connected to this study.