Less surgery may be just as good for advanced melanoma after immunotherapy

NCT ID NCT07049276

Recruiting now Disease control Sponsor: Melanoma Institute Australia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether removing only the largest affected lymph node (instead of all nearby lymph nodes) after 6 weeks of standard immunotherapy works just as well for stage III melanoma. About 1500 adults with stage IIIB-D melanoma will be randomly assigned to one of the two surgeries. The goal is to see if the less extensive surgery can prevent cancer from coming back while causing fewer side effects like swelling and wound problems.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUTANEOUS MELANOMA, STAGE III

Contacts and locations

Locations

Calvary Mater Newcastle
RECRUITING

Newcastle, New South Wales, 2298, Australia
Cedars-Sinai Medical Centre
NOT_YET_RECRUITING

Los Angeles, California, 90025, United States
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Melanoma Institute Australia
RECRUITING

Wollstonecraft, New South Wales, 2065, Australia
San Maria della Misericordia Hospital
NOT_YET_RECRUITING

Perugia, Italy
Sheba Medical centre
RECRUITING

Ramat Gan, Tel Aviv, Israel
Sunnybrook Health Sciences Centre
NOT_YET_RECRUITING

Toronto, Ontario, Canada
The Royal Marsden
NOT_YET_RECRUITING

London, United Kingdom

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