Brain radiation boost may improve melanoma treatment, new trial investigates
NCT ID NCT03340129
First seen Jan 11, 2026 · Last updated Jun 14, 2026 · Updated 26 times
Summary
This study compares two treatments for people with advanced melanoma that has spread to the brain. One group gets standard immunotherapy drugs (ipilimumab and nivolumab) alone, while the other group also receives targeted radiation to brain tumors. The goal is to see if adding radiation helps control the disease and reduces deaths from brain-related causes. About 218 adults with untreated brain metastases are being recruited.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alfred Hospital
RECRUITINGMelbourne, Victoria, 3004, Australia
Contact
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Calvary Mater NewcastleHospital
RECRUITINGWaratah, New South Wales, 2298, Australia
Contact
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Melanoma Institute Australia
RECRUITINGWollstonecraft, New South Wales, 2065, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oslo Univesity Hospital Radiumhospitalet
TERMINATEDOslo, Oslo, 0379, Norway
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Peter MacCallum Cancer Centre
RECRUITINGEast Melbourne, Victoria, 3002, Australia
Contact
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Princess Alexandra Hospital
RECRUITINGWoolloongabba, Queensland, 4102, Australia
Contact
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
Contact
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Sir Charles Gairdner Hosptial
RECRUITINGPerth, Western Australia, 6009, Australia
Contact
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Westmead Hospital
RECRUITINGSydney, New South Wales, 2145, Australia
Contact
Contact
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.