Mediterranean diet tested for brain and body benefits in seniors
NCT ID NCT06287489
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed trial tested whether a 3-month Mediterranean diet could improve thinking and physical abilities in 57 older adults who feel their memory is slipping but still score normally on tests. Participants ate either a Mediterranean diet or their usual diet, then switched. Researchers used brain scans and blood tests to explore how the diet might work.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mediterranean diet
- What this could lead to
- If it works, this could point toward a simple dietary approach to help maintain thinking and physical abilities in older adults worried about memory decline.
- What could go wrong
- This is a small, completed trial with only 57 participants. The diet lasted only 3 months, so any benefits may be short-lived or not apply to everyone. Results are not yet published.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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57 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Dec 2024
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Subjective cognitive decline (SCD)-plus subjects, individuals must meet five criteria: 1. Subjective memory decline without impairment in other cognitive domains (MMSE \> 26; MMSE \> 14 for \<6 years of education). 2. Onset of subjective cognitive decline within the past 5 years. 3. Age at the onset of subjective cognitive decline is \>60 years. 4. Concern and preoccupation with memory decline. 5. Perceived functional decline relative to peers and meet one of three criteria: a. Caregiver perceives cognitive decline; b. Carries APOE ε4 genotype; c. Clinical evidence of preclinical Alzheimer's disease biomarkers. Exclusion Criteria: Exclude individuals who: 1. Cannot comply with or accept the dietary intervention (e.g., dietary restrictions, vegetarianism, lactose intolerance). 2. Have walking speed ≤ 0.3 meters/second. 3. Have significant medical conditions affecting physical and cognitive functions. 4. Have chronic kidney disease (eGFR \<30 ml/min/1.73m2) or undergo dialysis. 5. Experience poorly controlled cardiovascular diseases or malignant tumors. 6. Have severe visual and hearing impairments preventing assessments. 7. Have undergone hormone therapy in the preceding three months or are expected to during the trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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