Medical cannabis studied as a remedy for chemo side effects
NCT ID NCT07374939
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This observational study will follow 50 people receiving chemotherapy that often causes nausea and vomiting. Researchers want to see if those who use medical cannabis on their own have less nausea, better appetite, and fewer other side effects compared to those who don't use it. Participants will fill out diaries and questionnaires over 6 to 12 weeks.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The MOSAIC study aims to enroll 50 participants. The study population consists of both males and females, aged 21 years or older, who are initiating first-line moderately or highly emetogenic chemotherapy, as defined by MASCC/NCCN criteria. Participants must be able to understand and communicate in English, and meet the various inclusion and exclusion criteria to be enrolled into this study.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Have a diagnosis of cancer with no previous chemotherapy treatments (aside from current treatment) * Be scheduled to receive treatment with a chemotherapeutic agent that is classified by the National Comprehensive Cancer Network (NCCN) as having a high emetogenic potential (\>90% incidence) or moderate emetogenic potential (30-90% incidence). * Must be scheduled for a minimum of 3 additional chemotherapy cycles at the time of enrollment. * Chemotherapy agents may be given intravenously or orally. * Chemotherapy cycles must be at least two weeks apart. * For the purposes of this study, Day 1 is defined as the day of chemotherapy administration. * Chemotherapy may be for adjuvant, neoadjuvant, curative, or palliative intent. * Highly emetogenic - common types of chemotherapy * AC combination defined as any chemotherapy regimen that contains an anthracycline and cyclophosphamide * Carboplatin AUC ≥4 * Carmustine \>250 mg/m2 * Cisplatin * Cyclophosphamide \>1,500 mg/m2 * Dacarbazine * Doxorubicin ≥60 mg/m2 * Epirubicin \>90 mg/m2 * Ifosfamide ≥2 g/m2 per dose * Mechlorethamine * Streptozocin * Moderately emetogenic - common types of chemotherapy: * Aldesleukin \>12-15 million IU/m2 * Amifostine \>300 mg/m2 * Arsenic trioxide * Azacitidine * Bendamustine * Busulfan * Carboplatin AUC \<4 * Carmustined ≤250 mg/m2 * Clofarabine * Cyclophosphamide ≤1500 mg/m2 * Cytarabine \>200 mg/m2 * Dactinomycin * Daunorubicin * Dual-drug liposomal encapsulation of cytarabine and daunorubicin * Dinutuximab * Doxorubicind \<60 mg/m2 * Epirubicind ≤90 mg/m2 * Idarubicin * Ifosfamided \<2 g/m2 per dose * Interferon alfa ≥10 million IU/m2 * Irinotecan * Irinotecan (liposomal) * Melphalan * Methotrexated ≥250 mg/m2 * Oxaliplatin * Temozolomide * Trabectedin * Be willing to commit to the suggested medication dosing and delivery method, completing evaluation instruments, and attending all study visits. * Be able to understand English (all assessment instruments are in English). * Be 21 years of age or older. * Give informed consent. * Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control, or abstinence) for the duration of the study. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her study physician immediately. Exclusion Criteria: * Participants must not: * Use of any THC-containing cannabis products within 30 days prior to enrollment, verified by participant self-report. Allowable: Use of hemp-derived CBD products containing \< 0.3 % THC is permitted, consistent with the 2018 Agriculture Improvement Act (federal definition of hemp). Use of CBD products will be documented in baseline case report forms. * Have any allergies to cannabis or contraindication for cannabis. * Have an active or recent (\< 6 months) substance use disorder, as determined by medical history. * Have recently quit smoking (\< 6 months) or are actively engaged in a smoking-cessation program. * Have a history of severe anxiety or paranoia on prior exposure to cannabis. * Have a previous diagnosis of bipolar disorder or schizophrenia. * Be pregnant or nursing. * Have had a prior stroke. * Have moderate or severe chronic obstructive pulmonary disease (COPD), defined as FEV₁ \< 50 % predicted or current use of home supplemental oxygen.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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