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Medical cannabis studied as a remedy for chemo side effects

NCT ID NCT07374939

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study will follow 50 people receiving chemotherapy that often causes nausea and vomiting. Researchers want to see if those who use medical cannabis on their own have less nausea, better appetite, and fewer other side effects compared to those who don't use it. Participants will fill out diaries and questionnaires over 6 to 12 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The MOSAIC study aims to enroll 50 participants. The study population consists of both males and females, aged 21 years or older, who are initiating first-line moderately or highly emetogenic chemotherapy, as defined by MASCC/NCCN criteria. Participants must be able to understand and communicate in English, and meet the various inclusion and exclusion criteria to be enrolled into this study.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of cancer with no previous chemotherapy treatments (aside from current treatment) * Be scheduled to receive treatment with a chemotherapeutic agent that is classified by the National Comprehensive Cancer Network (NCCN) as having a high emetogenic potential (\>90% incidence) or moderate emetogenic potential (30-90% incidence). * Must be scheduled for a minimum of 3 additional chemotherapy cycles at the time of enrollment. * Chemotherapy agents may be given intravenously or orally. * Chemotherapy cycles must be at least two weeks apart. * For the purposes of this study, Day 1 is defined as the day of chemotherapy administration. * Chemotherapy may be for adjuvant, neoadjuvant, curative, or palliative intent. * Highly emetogenic - common types of chemotherapy * AC combination defined as any chemotherapy regimen that contains an anthracycline and cyclophosphamide * Carboplatin AUC ≥4 * Carmustine \>250 mg/m2 * Cisplatin * Cyclophosphamide \>1,500 mg/m2 * Dacarbazine * Doxorubicin ≥60 mg/m2 * Epirubicin \>90 mg/m2 * Ifosfamide ≥2 g/m2 per dose * Mechlorethamine * Streptozocin * Moderately emetogenic - common types of chemotherapy: * Aldesleukin \>12-15 million IU/m2 * Amifostine \>300 mg/m2 * Arsenic trioxide * Azacitidine * Bendamustine * Busulfan * Carboplatin AUC \<4 * Carmustined ≤250 mg/m2 * Clofarabine * Cyclophosphamide ≤1500 mg/m2 * Cytarabine \>200 mg/m2 * Dactinomycin * Daunorubicin * Dual-drug liposomal encapsulation of cytarabine and daunorubicin * Dinutuximab * Doxorubicind \<60 mg/m2 * Epirubicind ≤90 mg/m2 * Idarubicin * Ifosfamided \<2 g/m2 per dose * Interferon alfa ≥10 million IU/m2 * Irinotecan * Irinotecan (liposomal) * Melphalan * Methotrexated ≥250 mg/m2 * Oxaliplatin * Temozolomide * Trabectedin * Be willing to commit to the suggested medication dosing and delivery method, completing evaluation instruments, and attending all study visits. * Be able to understand English (all assessment instruments are in English). * Be 21 years of age or older. * Give informed consent. * Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control, or abstinence) for the duration of the study. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her study physician immediately. Exclusion Criteria: * Participants must not: * Use of any THC-containing cannabis products within 30 days prior to enrollment, verified by participant self-report. Allowable: Use of hemp-derived CBD products containing \< 0.3 % THC is permitted, consistent with the 2018 Agriculture Improvement Act (federal definition of hemp). Use of CBD products will be documented in baseline case report forms. * Have any allergies to cannabis or contraindication for cannabis. * Have an active or recent (\< 6 months) substance use disorder, as determined by medical history. * Have recently quit smoking (\< 6 months) or are actively engaged in a smoking-cessation program. * Have a history of severe anxiety or paranoia on prior exposure to cannabis. * Have a previous diagnosis of bipolar disorder or schizophrenia. * Be pregnant or nursing. * Have had a prior stroke. * Have moderate or severe chronic obstructive pulmonary disease (COPD), defined as FEV₁ \< 50 % predicted or current use of home supplemental oxygen.

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Conditions

The condition(s) this trial relates to.

cancer Nausea Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.