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Small study tests exercise safety in kids with MCADD

NCT ID NCT06796530

Knowledge-focused Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed pilot study looked at how high-intensity exercise affects children with MCADD, a rare genetic condition that makes it hard to break down certain fats for energy. Eight participants (4 with MCADD and 4 healthy controls) aged 8-17 did cycling tests and high-intensity circuit training. Researchers measured blood glucose and other metabolic markers before and after exercise to check safety and energy use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help develop safe exercise guidelines for children with MCADD.
What could go wrong
This is a very small pilot study with only 4 patients, so results may not apply to everyone. The main goal is safety, not treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8 people

The number who actually took part.

Started

Jan 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 8-17y old * Control subjects matched by sex, age, and self reported Tanner stage. * All children: height and weight between P5-P95 Exclusion Criteria: * No daily medication use * No conditions other than MCADD that restrict sports participation or physiology (e.g., no heart diseases, diabetes). * \< P5 or \> P95 on the height-weight curve * No neuromotor developmental delay (e.g., delayed achievement of motor milestones) * No recent immobilization (\<6 months) * No surgeries involving the musculoskeletal system

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Conditions

The condition(s) this trial relates to.

medium chain acyl-CoA dehydrogenase deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Medium-chain acyl-coa dehydrogenase deficiency

Contacts and locations

Locations

  • Ghent University Hospital

    Ghent, East Flanders, 9000, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.