New heart drug shows promise for thick heart muscle

NCT ID NCT05414175

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Feb 01, 2026 · Last updated May 23, 2026 · Updated 13 times

Summary

This study tested a drug called mavacamten in 38 Japanese adults with a condition that makes the heart muscle too thick and stiff, blocking blood flow. The goal was to see if the drug could improve heart function and reduce symptoms like shortness of breath and chest pain over 30 weeks. Participants took the pill daily and had regular heart scans and questionnaires to track their progress.

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Contacts and locations

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Locations

Local Institution - 0001

Itabashi-Ku, Tokyo, 173-0003, Japan
Local Institution - 0003

Fuchu-Shi, Tokyo, 1830003, Japan
Local Institution - 0005

Shinjuku-Ku, Tokyo, 160-8582, Japan
Local Institution - 0007

Koto-Ku, Tokyo, 135-0061, Japan
Local Institution - 0009

Chuo-Ku, Tokyo, 104-0044, Japan
Local Institution - 0010

Bunkyo-Ku, Tokyo, 113-0033, Japan
Local Institution - 0011

Suita-Shi, Osaka, 565-0871, Japan
Local Institution - 0012

Hamamatsu, Shizuoka, 431-3192, Japan
Local Institution - 0013

Shinjuku-ku, Tokyo, 162-8666, Japan
Local Institution - 0014

Suita, Osaka, 564-8565, Japan
Local Institution - 0015

Nankoku-shi, Kochi, 783-8505, Japan
Local Institution - 0016

Kobe, Hyōgo, 650-0047, Japan
Local Institution - 0017

Tsukuba, Ibaraki, 305-0005, Japan
Local Institution - 0018

Osaka, 558-8558, Japan
Local Institution - 0019

Yokohama, Kanagawa, 227-8501, Japan
Local Institution - 0020

Uwajima, Ehime, 798-8510, Japan
Local Institution - 0023

Kanazawa, Ishikawa-ken, 920-8641, Japan
Local Institution - 0026

Himeji-Shi, Hyōgo, 672-8044, Japan
Local Institution - 0027

Sendai, Miyagi, 980-8574, Japan
Local Institution - 0028

Tsu, Mie-ken, 514-8507, Japan

Conditions

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CARDIOMYOPATHY, HYPERTROPHIC OBSTRUCTIVE