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Parent coaching may rewire kids' brains to fight depression

NCT ID NCT06725160

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether teaching mothers with depression to encourage positive emotions in their young children (ages 4-6) can increase the child's brain response to rewards. 180 mother-child pairs will be randomly assigned to either a parent-coaching program or general parenting support. Brain activity is measured before and after using EEG.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Parent coaching (behavioral intervention)
What this could lead to
If successful, this could point toward a simple parenting strategy to strengthen children's brain reward systems, potentially reducing future depression risk.
What could go wrong
This is a small, early mechanistic study (180 participants) looking at brain signals, not clinical outcomes. The coaching is brief (3 sessions) and may not produce lasting changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Mothers: * Birth mother (biologically female, any gender) * Providing regular care for participating child (i.e., at least 50% of time) * Elevated, clinically significant levels of depression (16 or higher on CES-D) * Aged 18+ Exclusion Criteria for Mothers: * Lifetime history of a bipolar disorder * Lifetime history of a psychotic disorder Inclusion Criteria for Participating Child: -Aged 4-6 years Exclusion Criteria for Participating Child: * T-score greater than 63 on the internalizing or externalizing composites of the CBCL * Lifetime history of a psychiatric illness * Lifetime history of neurodevelopmental disorder * Lifetime history of neurological disorder

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Conditions

The condition(s) this trial relates to.

Behavior Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Parent-child relations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

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