New hope for Hard-to-Treat cancers: targeted drug blocks key growth signal
NCT ID NCT06357988
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 23 times
Summary
This study tests a drug called vismodegib in people with advanced or treatment-resistant cancers (solid tumors, lymphoma, or multiple myeloma) that have specific mutations in the SMO or PTCH1 genes. The drug works by blocking a growth signal that cancer cells rely on. The goal is to see if it can shrink or slow tumor growth, but it is not expected to be a cure.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ECOG-ACRIN Cancer Research Group
Philadelphia, Pennsylvania, 19103, United States
Conditions
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