Can a liquid adhesive make clubfoot treatment stick better?
NCT ID NCT07154550
First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times
Summary
This study tests whether applying Mastisol, a liquid adhesive, during clubfoot casting helps babies with clubfeet get better faster and with fewer problems. Researchers will compare outcomes like how many weeks of casting are needed and how often complications like sores or swelling occur. The trial involves 100 infants starting treatment before 12 weeks old, with follow-up for up to 5 years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mastisol (liquid adhesive)
- What this could lead to
- If it works, this could make clubfoot casting more effective and reduce skin problems or the need for extra surgeries.
- What could go wrong
- This is a small, early-stage trial with only 100 infants. The adhesive might not improve outcomes and could cause skin irritation or other side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2026
- Expected to finish
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Nov 2032
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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0 to 12 weeks
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with bilateral clubfeet * Starting standard of care treatment with the Ponseti method between 0-12 weeks of age * For patients born pre-maturely their eligibility age will be based on a corrected gestational age * Patients for whom at least one parent/guardian is able to converse, read, and write in English Exclusion Criteria: * Patients who do not have bilateral clubfoot * Patients who are starting treatment for clubfoot after 12 weeks of age * Patients whose parents/guardians are unable to converse, read, and write in English * Patients whose parents/guardian do not provide or are not able to provide informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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UW-Health Pediatric Orthopedics Clinics
RECRUITINGMadison, Wisconsin, 53792, United States
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