Hidden high blood pressure: which monitoring method works best?
NCT ID NCT02804074
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at people with masked hypertension, where blood pressure is normal at the doctor's office but high during daily life. It compares two treatment strategies: one based on office readings and another based on 24-hour ambulatory monitoring. Over 4 years, researchers will track heart and kidney health in 1,240 participants to see which approach leads to better outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Optimization of antihypertensive treatment based on office blood pressure or 24-hour ambulatory blood pressure monitoring
- What this could lead to
- If successful, this could show that using 24-hour blood pressure monitoring leads to better heart and kidney health than standard office checks for people with masked hypertension.
- What could go wrong
- This is a large but early-stage comparison study, not testing a new drug. Results may not show a clear benefit, and individual responses to treatment adjustments can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,240 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2018
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male and female subjects * Age 35-80 years * Masked uncontrolled (in treatment) hypertension: office BP \<140/90 mmHg, and one or more of the following situations: * Ambulatory daytime BP \>135/85 mmHg * Ambulatory night-time ABP \> 120/70 mmHg * Ambulatory 24h ABP \>130/80 mmHg * eGFR ≥45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009) Exclusion Criteria: * eGFR \<45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009), and in particular severe chronic renal failure defined as serum creatinine \> 250 umol/l; * Patients in unstable clinical conditions; * Known secondary hypertension; * Orthostatic hypotension (SBP fall \> 20 mmHg on standing); * Dementia (clinical diagnosis); * Hepatic disease as determined by either AST or ALT values \> 2 times the upper limit of normal * History of gastrointestinal surgery or disorders which could interfere with drug absorption * Known allergy or contraindications to one of the drugs to be administered in the study * History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years * History of clinically significant autoimmune disorders such as systemic lupus erythematosus. * History of drug or alcohol abuse within the last 5 years * History of non-compliance to medical regimens and/or patients who are considered potentially unreliable * Inability or unwillingness to give free informed consent * Pregnancy or planned pregnancy during study period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fundacion Venezolana de Hipertension Arterial/Instituto de Enfermedades Cardiovasculares de LUZ
RECRUITINGMaracaibo, Venezuela
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Istituto Auxologico Italiano
NOT_YET_RECRUITINGMilan, Italy