New drug combo may reduce side effects in kidney transplant recipients
NCT ID NCT06034925
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two different medicines to prevent CMV infection in 70 kidney transplant patients at high risk. One group received the standard drug valganciclovir, while the other received maribavir plus acyclovir. The goal was to see which approach caused fewer side effects like low white blood cell counts, while still preventing CMV infection.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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70 people
The number who actually took part.
- Started
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Nov 2023
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Kidney transplant recipient at study institution * =7 days of transplant * Received at least one dose of rATG induction or patient is D+/R- CMV serostatus Exclusion Criteria: * Age \<18 years at time of transplant * Recipient of pancreas, liver, heart, lung transplant * Recipient of investigational, non-FDA approved medication
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Blood test could tailor CMV prevention after stem cell transplants
- Massive UK study tracks cancer after organ transplants
- New drug may offer safer CMV prevention for kidney transplant patients
- New hope for lung transplant patients: drug may block dangerous virus
- New blood test may help protect kids from post-transplant infection