Hope for rare liver itch: new drug trial targets unbearable symptoms
NCT ID NCT06553768
First seen Jan 10, 2026 · Last updated May 24, 2026 · Updated 25 times
Summary
This study tests if maralixibat can safely reduce severe itching in children and adults with rare cholestatic liver diseases who have not responded to other treatments. Participants receive either the drug or a placebo, and researchers measure changes in itch severity and bile acid levels. The goal is to ease symptoms for those with limited options.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Azienda Ospedaliera Papa Giovanni XXIII
Bergamo, 24127, Italy
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Children's Hospital Los Angeles (CHLA)
Los Angeles, California, 90027, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Hospital Sírio-Libanês
São Paulo, Brazil
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Hospital Universitario La Paz
Madrid, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, Spain
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Hospital da Criança Santo Antonio
Porto Alegre, Brazil
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Hospital de Criança de Brasília (HCB)
Brasília, Brazil
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Hotel Dieu de France
Beirut, Lebanon
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Hôpital Kremlin Bicêtre
Paris, France
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Hôpitaux Universitaires de Marseille Timone
Marseille, 13005, France
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ISMETT - Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
Palermo, 90127, Italy
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Instytut Pomnik Centrum Zdrowia Dziecka
Warsaw, Poland
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King's College Hospital NHS Foundation Trust
London, United Kingdom
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Lurie Children's Hospital
Chicago, Illinois, 60611, United States
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Morgan Stanley Children's Hospital - NewYork Presbyterian
New York, New York, 10032, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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NYU Langone Health
New York, New York, 10016, United States
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Ospedale Pediatrico Bambino Gesu
Rome, 00165, Italy
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Stanford Children's Health in Palo Alto
Palo Alto, California, 94304, United States
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Stollery Children's Hospital
Edmonton, Alberta, T6G 2B7, Canada
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University of Utah
Salt Lake City, Utah, 84112, United States
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Universitätsklinikum Hamburg Eppendorf - Klinik für Kinder- und Jugendmedizin
Hamburg, Germany
Conditions
Explore the condition pages connected to this study.