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Could hand therapy replace surgery for carpal tunnel?

NCT ID NCT07654621

Symptom relief Sponsor: Universidad Europea de Valencia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a combination of manual therapy and nerve stimulation can relieve symptoms of moderate carpal tunnel syndrome as well as surgery recovery does. About 150 adults aged 30-50 with confirmed moderate carpal tunnel will be split into two groups: one gets the non-surgical therapy, the other gets standard rehab after surgery. The goal is to see if the non-surgical approach can reduce pain and improve hand function, potentially offering an alternative to going under the knife.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 30 to 50 years. * Clinical diagnosis of moderate carpal tunnel syndrome confirmed by nerve conduction studies according to the American Association of Electrodiagnostic Medicine criteria. * Symptoms persisting for at least 3 months. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Previous surgery for carpal tunnel syndrome in the affected hand (experimental group only). * Severe carpal tunnel syndrome requiring urgent surgical intervention. * History of wrist fracture or major upper-limb trauma affecting the study limb. * Pregnancy. * Diabetes mellitus or other systemic diseases associated with peripheral neuropathy. * Cervical radiculopathy or other neurological disorders affecting the upper limb. * Rheumatoid arthritis or other inflammatory arthropathies involving the wrist. * Previous corticosteroid injection for carpal tunnel syndrome within the last 3 months. * Contraindications to percutaneous neuromodulation (e.g., pacemaker, active infection at the treatment site, bleeding disorders, or anticoagulant therapy when considered clinically inappropriate). * Inability to comply with the study protocol or follow-up assessments.

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome peripheral nervous system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carpal tunnel syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • European University of Valencia

    Valencia, Valencia, 46010, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.