Could a simple sugar alcohol prevent delirium after a heart attack?
NCT ID NCT06759259
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving mannitol, a substance that reduces brain swelling, could prevent delirium in older adults hospitalized for a heart attack. Fifty patients aged 65 and older with high inflammation levels were included. The goal was to see if mannitol could lower the chance of developing confusion and other delirium symptoms during their hospital stay.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mannitol
- What this could lead to
- If it works, this could point toward a simple, low-cost way to prevent delirium in older heart attack patients.
- What could go wrong
- This is a very small, single-center study with only 50 participants. Results may not apply to all patients, and the effect may be modest or absent.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
50 people
The number who actually took part.
- Started
-
Dec 2024
- Finished
-
Oct 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients in the first day of development of myocardial infarction with signs of systemic inflammation and initial normal mental status and the absence of previously known pathological processes of the brain and psychiatric disorders.
- Ages
-
65 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 65 and over * Myocardial infarction in the first day of illness ("pain to door" time \< 254 hours) * Serum CRP \> 25 mg/L Exclusion Criteria: * A known pathological process in the brain, psychiatric disorders * Impossibility of conducting an assessment CAM-ICU
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cardiology Reserch Institute Tomsk National Research Centre
Tomsk, Tomsk Oblast, 634012, Russia
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