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Massive study aims to rewrite the rules for malignant hypertension

NCT ID NCT03755726

Knowledge-focused Sponsor: Centre Hospitalier de PAU Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is building a large database of 1,200 people with malignant hypertension, a severe form of high blood pressure that can damage organs quickly. Researchers will track patients for five years to learn how the disease behaves today and how doctors treat it. The goal is to update the definition and diagnosis of the condition, and eventually set the stage for better clinical trials and treatment recommendations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could lead to better diagnostic criteria and more effective treatment guidelines for malignant hypertension.
What could go wrong
This is an observational registry, not a treatment trial. It will not directly test any new therapy, and results may take years to influence patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2019

Expected to finish

Sep 2034

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with malignant hypertension

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Malignant hypertension according to the classic definition (Severe hypertension, above 180/110 associated with severe hypertensive retinopathy) * Severe hypertension (above 180/110) associated with acute damage of 3 target organ due to high blood pressure Exclusion Criteria: * Age \< 18 years old * Patients who cannot freely give their consent, or patients who refuse to participate * Dialysis

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Conditions

The condition(s) this trial relates to.

malignant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malignant hypertension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    37 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP Bichat

    RECRUITING

    Paris, 75877, France

  • Avicenne APHP

    RECRUITING

    Bobigny, 93009, France

  • CH Martigues

    RECRUITING

    Martigues, 13500, France

  • CH Métropole

    RECRUITING

    Chambéry, 73011, France

  • CH d'Annecy

    RECRUITING

    Annecy, France

  • CH de Chalon sur Saone

    RECRUITING

    Chalon-sur-Saône, France

  • CH de Dinard

    RECRUITING

    Dinard, 35800, France

  • CH de Libourne

    RECRUITING

    Libourne, 33505, France

  • CH de PAU

    RECRUITING

    Pau, 64000, France

  • CH de St Nazaire

    RECRUITING

    Saint-Nazaire, 44606, France

  • CH de Valenciennes

    RECRUITING

    Valenciennes, France

  • CH de la côte Basque

    RECRUITING

    Bayonne, 64109, France

  • CHRU de Lille

    RECRUITING

    Lille, 59037, France

  • CHU - Hôpital Laennec

    RECRUITING

    Nantes, 44800, France

  • CHU - Hôpital St André

    RECRUITING

    Bordeaux, 33000, France

  • CHU Michallon

    RECRUITING

    Grenoble, 38043, France

  • CHU de Clermont FERRAND

    RECRUITING

    Clermont-Ferrand, France

  • CHU de Montellier

    RECRUITING

    Montpellier, France

  • CHU de Pointe à Pitre

    NOT_YET_RECRUITING

    Pitres, 97159, France

  • CHU de Poitiers

    RECRUITING

    Poitiers, 86021, France

  • CHU de ROUEN

    RECRUITING

    Rouen, 76000, France

  • CHU de Rennes

    RECRUITING

    Rennes, 35033, France

  • CHU de St Etienne

    RECRUITING

    Saint-Etienne, 42055, France

  • CHU de Strasbourg

    RECRUITING

    Strasbourg, 67000, France

  • CHU de Toulouse Rangueil

    RECRUITING

    Toulouse, 31059, France

  • CHU de Tours

    RECRUITING

    Tours, 37044, France

  • Clinique Vert Coteau

    RECRUITING

    Marseille, 13012, France

  • Clinique sainte Clotilde

    RECRUITING

    Saint-Denis, 97400, France

  • Fondation Adolphe de Rothschild

    RECRUITING

    Paris, France

  • Hopital de la conception

    RECRUITING

    Marseille, 13385, France

  • Hôpital Européen Georges Pompidou

    RECRUITING

    Paris, 75015, France

  • Hôpital Henri Mondor

    RECRUITING

    Créteil, France

  • Hôpital Saint Joseph

    RECRUITING

    Paris, 75014, France

  • Hôpital Tenon

    RECRUITING

    Paris, France

  • National Institute of Cardiology

    NOT_YET_RECRUITING

    Warsaw, Poland

  • Pôle Santé Sud

    RECRUITING

    Le Mans, France

  • hôpital de Haguenau

    RECRUITING

    Haguenau, 67504, France