Malaria vaccine plus bednets: a One-Two punch?
NCT ID NCT04327440
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study in Malawi looks at whether giving children the RTS,S malaria vaccine along with special insecticide-treated bednets (PBO nets) can lower malaria infection and spread. About 1,700 children aged 7 months to 10 years took part. The goal is to see how well these two tools work together and to prepare for a larger future study.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- RTS,S/AS01 malaria vaccine and insecticide-treated bednets (PBO nets)
- What this could lead to
- If successful, this could show that combining the RTS,S vaccine with special bednets offers better protection against malaria than either alone.
- What could go wrong
- This is a small, early-phase study focused on feasibility, not a large trial. The vaccine's protection wanes over time, and results may not apply to other regions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,691 people
The number who actually took part.
- Started
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Feb 2020
- Finished
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Jun 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Children whose age is between 7 and 18 months, which indicates they could receive at least 3 RTS,S doses, will be eligible to participate. Following informed consent from parents/guardians, up to two children who are 18 months but ≤10 years of age, from the same household as the vaccine-eligible child, will also be enrolled. Only households whose families intend to stay in the area for at least six months and whose eligible children will also be expected to use an assigned health center for child vaccinations will be eligible to participate.
- Ages
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7 months to 10 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children aged 7 to 18 months of age (age-eligible for at least 3 doses of RTS,S doses) OR being one of not more than two children living in the household of an enrolled age-eligible child and being \>18 mos and \< 10 years of age. * Not on cotrimoxazole prophylaxis for HIV infection * Weight \>5 kg * Permanent residence of Health Centre (HC) catchment area * Residence within 10 km from the HC * Written informed consent from parent/guardian for the child to participate in the study Exclusion Criteria: Non-residents of the catchment area and visitors to the study area will be excluded because the study requires follow-up for at least 6 months and access to interventions such as conventional, PBO nets and malaria vaccination.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Malawi College of Medicine
Blantyre, 3, Malawi