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Experimental combo for advanced cancers shows early promise

NCT ID NCT05147272

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 26 times

Summary

This early-phase study tested a new drug, RP-6306, combined with the chemotherapy gemcitabine in 67 adults with advanced solid tumors that had stopped responding to other treatments. The main goals were to find a safe dose and check for side effects. The study was terminated early, but the data helps guide future research.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • # 1004, Memorial Sloan Kettering Cancer Institute

    New York, New York, 10065, United States

  • # 1008, Columbia University

    New York, New York, 10032, United States

  • # 1010, University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • # 1016, Mayo Clinic

    Rochester, Minnesota, 55902, United States

  • # 1017, Mayo Clinic

    Jacksonville, Florida, 32224, United States

  • # 1018, Mayo Clinic

    Phoenix, Arizona, 85054, United States

  • # 1019, UCLA, Westwood Cancer Center

    Los Angeles, California, 90095, United States

  • # 1022, Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • # 1023, START Midwest

    Grand Rapids, Michigan, 49546, United States

  • # 2001, Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2C1, Canada

  • # 3003, Sarah Cannon Research Institute

    London, United Kingdom

Conditions

Explore the condition pages connected to this study.