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Can a simple drug combo make intubation safer for seniors?

NCT ID NCT07258628

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving magnesium sulfate and fentanyl before intubation (placing a breathing tube) can prevent sudden spikes in blood pressure and heart rate in patients aged 50 and older. 76 participants were split into three groups: magnesium alone, fentanyl alone, or both drugs together. The goal was to see which approach best keeps vital signs stable during this critical procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
magnesium sulfate and fentanyl
What this could lead to
If successful, this could lead to a simple drug combination to make intubation safer for older adults by preventing sudden blood pressure and heart rate spikes.
What could go wrong
This is a small, completed trial with only 76 participants, so results may not apply to all patients. The drugs themselves can have side effects like low blood pressure or breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

76 people

The number who actually took part.

Started

Oct 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 50 years * Patients scheduled for elective surgery under general anesthesia * Patients requiring endotracheal intubation with a single-lumen tube * Provision of written informed consent Exclusion Criteria: * Known renal or hepatic insufficiency * Thyroid dysfunction * Uncontrolled hypertension * Suspected difficult airway (Mallampati ≥ 3 or history of difficult intubation) * Known allergy or hypersensitivity to study medications * Myocardial infarction within the past 3 months * Presence of heart block * Preoperative hypermagnesemia Withdrawal Criteria: * Laryngoscopy time exceeding 20 seconds * Withdrawal of informed consent * Patient withdrawal from the study at any time

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Conditions

The condition(s) this trial relates to.

hypertensive disorder Tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension Tachycardia

Contacts and locations

Locations

  • Ankara Bilkent City Hospital, Department of Anesthesiology and Reanimation

    Ankara, Ankara, 06800, Turkey (Türkiye)

  • Ankara City Hospital

    Ankara, 06800, Turkey (Türkiye)

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