Can magnesium and fentanyl protect older patients during anesthesia?
NCT ID NCT07258628
First seen Dec 08, 2025 · Last updated Jun 20, 2026 · Updated 37 times
Summary
This completed trial tested whether giving magnesium sulfate and fentanyl before intubation can prevent sudden spikes in blood pressure and heart rate in patients aged 50 and older. 76 participants were randomly assigned to receive magnesium alone, fentanyl alone, or both. The study measured changes in blood pressure and heart rate at several time points after intubation.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ankara Bilkent City Hospital, Department of Anesthesiology and Reanimation
Ankara, Ankara, 06800, Turkey (Türkiye)
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Ankara City Hospital
Ankara, 06800, Turkey (Türkiye)
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
magnesium sulfate and fentanyl
What this could lead to
If effective, this combination could help older patients avoid dangerous blood pressure and heart rate spikes during anesthesia.
What could go wrong
This is a small, completed trial with 76 patients, so results may not apply to everyone. The drugs themselves can cause side effects like low blood pressure or breathing problems.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.