Could your own immune cells stop colon cancer returning?
NCT ID NCT05394714
First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This early-stage trial tests a new treatment called Magicell-NK for people with stage I or IIa colon cancer who have already had surgery to remove the tumor. The treatment uses a patient's own natural killer (NK) cells, which are grown and activated in a lab and then infused back into the body. The main goal is to check safety and find the best dose, with 18 participants receiving one of three dose levels.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Magicell-NK (a patient's own natural killer cells grown and activated in a lab)
- What this could lead to
- If it works, this could point toward a treatment to prevent colon cancer from coming back after surgery without needing chemotherapy.
- What could go wrong
- This is a very early, small Phase 1 trial with only 18 people, focused on safety. It may not show any benefit, and side effects like infusion reactions or immune overactivation are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 18 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2022
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. A dated and signed informed consent 2. Either gender and aged over 20 years old (inclusive) at date of consent 3. With histologically confirmed stage I or stage IIa colon cancer 4. Received curative colon resection within 4\~8 weeks prior to the screening visit and does not need adjuvant chemotherapy or radiotherapy 5. With no ≥ grade 3 postoperative complications or has been recovered and is suitable for study enrollment according to the investigator's judgment 6. With adequate hematology function: * Absolute neutrophil count (ANC) ≥ 1,500 cells/μL * Total white blood cell (WBC) ≥ 3,000 cells/μL * Platelets ≥ 100,000 counts/μL * Hemoglobin ≥ 9 g/dL 7. With adequate hepatic and renal function: * Serum creatinine ≤ 1.5 × Upper Limit of Normal (ULN) * Total bilirubin (TB) ≤ 1.5 × ULN * ALT and AST ≤ 2.5 × ULN * Alkaline phosphatase (ALP) ≤ 5X ULN 8. Negative response in HIV and syphilis test 9. Subject with childbearing potential must agree to abstain from intercourse or use highly effective contraceptives from when signing informed consent to the Final/ET Visit. 10. Performance status (ECOG) \< 2 11. Patients agree to be in compliant to clinical protocol planned treatment plan Exclusion Criteria: 1. Received any other investigational, anti-neoplastic medication (except squamous cell carcinoma, basal cell carcinoma, or carcinoma in situ of the skin, curatively treated with cryosurgery or surgical excision only), or immune cell therapy within 28 days prior to Day 1. 2. Currently under immunosuppressive or systemic steroid treatment with equivalent dosage higher than prednisolone 30 mg/day for more than 7 days within 14 days prior to Day 1 3. With known tumor metastasis or coexisting malignant disease 4. With ongoing acute diseases, or within the past 2 years having serious medical conditions (e.g. concomitant illness) such as cardiovascular (e.g. New York Heart Association grade III or IV), hepatic (e.g. Child-Pugh Class C), psychiatric condition (e.g. alcoholism, drug abuse), medical history, physical findings, or laboratory abnormality that, judged by the investigator, could interfere with the results of the trial or adversely affect the safety of the subject 5. Known hypersensitivity to aminoglycoside or bacitracin (e.g. Streptomycin, Gentamicin) 6. Known hypersensitivity to any of the components of Magicell-NK, including human serum albumin 7. Female subject who is lactating or has positive urine pregnancy test at screening
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Chang Gung Memorial Hospital, Linkou
RECRUITINGTaoyuan, 333, Taiwan
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