Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Could your own immune cells stop colon cancer returning?

NCT ID NCT05394714

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This early-stage trial tests a new treatment called Magicell-NK for people with stage I or IIa colon cancer who have already had surgery to remove the tumor. The treatment uses a patient's own natural killer (NK) cells, which are grown and activated in a lab and then infused back into the body. The main goal is to check safety and find the best dose, with 18 participants receiving one of three dose levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magicell-NK (a patient's own natural killer cells grown and activated in a lab)
What this could lead to
If it works, this could point toward a treatment to prevent colon cancer from coming back after surgery without needing chemotherapy.
What could go wrong
This is a very early, small Phase 1 trial with only 18 people, focused on safety. It may not show any benefit, and side effects like infusion reactions or immune overactivation are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2022

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. A dated and signed informed consent 2. Either gender and aged over 20 years old (inclusive) at date of consent 3. With histologically confirmed stage I or stage IIa colon cancer 4. Received curative colon resection within 4\~8 weeks prior to the screening visit and does not need adjuvant chemotherapy or radiotherapy 5. With no ≥ grade 3 postoperative complications or has been recovered and is suitable for study enrollment according to the investigator's judgment 6. With adequate hematology function: * Absolute neutrophil count (ANC) ≥ 1,500 cells/μL * Total white blood cell (WBC) ≥ 3,000 cells/μL * Platelets ≥ 100,000 counts/μL * Hemoglobin ≥ 9 g/dL 7. With adequate hepatic and renal function: * Serum creatinine ≤ 1.5 × Upper Limit of Normal (ULN) * Total bilirubin (TB) ≤ 1.5 × ULN * ALT and AST ≤ 2.5 × ULN * Alkaline phosphatase (ALP) ≤ 5X ULN 8. Negative response in HIV and syphilis test 9. Subject with childbearing potential must agree to abstain from intercourse or use highly effective contraceptives from when signing informed consent to the Final/ET Visit. 10. Performance status (ECOG) \< 2 11. Patients agree to be in compliant to clinical protocol planned treatment plan Exclusion Criteria: 1. Received any other investigational, anti-neoplastic medication (except squamous cell carcinoma, basal cell carcinoma, or carcinoma in situ of the skin, curatively treated with cryosurgery or surgical excision only), or immune cell therapy within 28 days prior to Day 1. 2. Currently under immunosuppressive or systemic steroid treatment with equivalent dosage higher than prednisolone 30 mg/day for more than 7 days within 14 days prior to Day 1 3. With known tumor metastasis or coexisting malignant disease 4. With ongoing acute diseases, or within the past 2 years having serious medical conditions (e.g. concomitant illness) such as cardiovascular (e.g. New York Heart Association grade III or IV), hepatic (e.g. Child-Pugh Class C), psychiatric condition (e.g. alcoholism, drug abuse), medical history, physical findings, or laboratory abnormality that, judged by the investigator, could interfere with the results of the trial or adversely affect the safety of the subject 5. Known hypersensitivity to aminoglycoside or bacitracin (e.g. Streptomycin, Gentamicin) 6. Known hypersensitivity to any of the components of Magicell-NK, including human serum albumin 7. Female subject who is lactating or has positive urine pregnancy test at screening

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Colon cancer stage I are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chang Gung Memorial Hospital, Linkou

    RECRUITING

    Taoyuan, 333, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.