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Could eye pigment levels predict vision damage in severe nearsightedness?

NCT ID NCT02205632

Knowledge-focused Sponsor: Poitiers University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study examined 39 people with severe nearsightedness to see if lower levels of a natural eye pigment (macular pigment) are linked to tiny cracks in the back of the eye called lacquer cracks. These cracks can lead to vision loss. The researchers measured the pigment's optical density and compared it between those with and without cracks. The goal was to better understand risk factors for eye damage in high myopia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward a way to identify high myopia patients at greater risk of vision damage, potentially guiding future prevention strategies.
What could go wrong
This is a small, completed observational study (39 people) that only looks for a link, not a treatment. The results may not apply to all patients or lead to any direct benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Feb 2014

Finished

Nov 2014

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>18 years-old * High axial myopia \< -6 dioptries * Presence or not of lacquer cracks in Bruch's membrane in one or both eyes * Patients with social security coverage Exclusion Criteria: * Age \<18 years-old * Amblyopia in the studied eye * Prior ocular surgery * Corneal disease or severe dry eye syndrome * Other retinal disease: diabetic retinopathy, age-related macular degeneration, macular hole, epiretinal membrane central * Extensive chorioretinal atrophy * Allergy to tropicamide * Pregnancy

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Conditions

The condition(s) this trial relates to.

degenerative myopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

High myopia

Contacts and locations

Locations

  • ophthalmology department, Poitiers University Hospital

    Poitiers, VIENNE, 86021, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.