Can a Tight-Control strategy tame lupus?
NCT ID NCT05714930
First seen Jun 22, 2026 · Last updated Jun 22, 2026
Summary
This study tests whether a 'treat-to-target' approach—where doctors adjust treatment every 6 weeks to aim for remission—works better than usual care for people with lupus. About 606 participants who are not in remission will be followed for 120 weeks. The goal is to see if this strategy reduces long-term organ damage and improves quality of life.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Charité - Berlin University of Medicine
RECRUITINGBerlin, 10117, Germany
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Kliniken Essen Mitte, Essen
RECRUITINGEssen, North Rhine-Westphalia, 45136, Germany
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LMU Munich
RECRUITINGMunich, Bavaria, 80336, Germany
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Medical University Hannover
RECRUITINGHanover, Lower Saxony, 30625, Germany
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Rheumazentrum Ruhrgebiet Herne, Ruhr University Bochum
RECRUITINGHerne, North Rhine-Westphalia, 44649, Germany
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UKSH Campus Kiel
RECRUITINGKiel, 24105, Germany
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University Clinic Düsseldorf
RECRUITINGDüsseldorf, North Rhine-Westphalia, 40225, Germany
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University Clinic Erlangen
NOT_YET_RECRUITINGErlangen, Bavaria, 91054, Germany
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University Clinic Frankfurt
RECRUITINGFrankfurt am Main, Hesse, 60590, Germany
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University Clinic Freiburg
RECRUITINGFreiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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University Clinic Heidelberg
RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
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University Clinic Mainz
RECRUITINGMainz, Rhineland-Palatinate, 55131, Germany
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University Clinic Münster
RECRUITINGMünster, North Rhine-Westphalia, 48149, Germany
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University Medical Center TU Dresden
RECRUITINGDresden, Saxony, 01307, Germany
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
treat-to-target strategy (tight control with frequent visits and treatment adjustments)
What this could lead to
If successful, this approach could become a standard way to manage lupus, helping more patients reach remission and prevent long-term organ damage.
What could go wrong
This is a strategy trial, not testing a new drug, so benefits may be modest. Results depend on how well doctors and patients follow the plan, and the study is still recruiting.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.