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Promising lung cancer drug trial halted midway

NCT ID NCT04154956

First seen May 20, 2026 · Last updated May 24, 2026 · Updated 1 time

Summary

This study tested a new drug, tusamitamab ravtansine, against standard chemotherapy (docetaxel) in 389 adults with advanced non-small-cell lung cancer that had stopped responding to previous treatments. The drug targets a specific marker (CEACAM5) on cancer cells. The trial was terminated early, so final results are not yet available.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Ca & Hem Center Of W Michigan- Site Number : 8400016

    Grand Rapids, Michigan, 49546, United States

  • Centro Avancado de Oncologia CECAN - Liga Contra o Cancer- Site Number : 0760026

    Natal, Rio Grande do Norte, 59062-000, Brazil

  • Centro Regional Integrado De Oncologia - CRIO- Site Number : 0760002

    Fortaleza, Ceará, 60336-232, Brazil

  • Clínica de Oncologia Reichow Site Number : 0760023

    Blumenau, Santa Catarina, 89010-340, Brazil

  • Florida Cancer Specialists North Division- Site Number : 8400019

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists South Division- Site Number : 8400020

    Fort Myers, Florida, 33901, United States

  • Hospital Sirio Libanes- Site Number : 0760018

    São Paulo, São Paulo, 01308050, Brazil

  • Hospital de Base Sao Jose do Rio Preto Site Number : 0760001

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Investigational Site Number : 0320001

    Buenos Aires, 1426ANZ, Argentina

  • Investigational Site Number : 0320002

    Salta, 4400, Argentina

  • Investigational Site Number : 0320003

    Viedma, Río Negro Province, R8500ACE, Argentina

  • Investigational Site Number : 0320004

    Buenos Aires, C1125ABD, Argentina

  • Investigational Site Number : 0320009

    CABA, Buenos Aires, C1019ABS, Argentina

  • Investigational Site Number : 0320012

    Capital Federal, Buenos Aires, 1012, Argentina

  • Investigational Site Number : 0320014

    Córdoba, ZCX5000AAI, Argentina

  • Investigational Site Number : 0360001

    Woolloongabba, Queensland, 4102, Australia

  • Investigational Site Number : 0360002

    Blacktown, New South Wales, 2148, Australia

  • Investigational Site Number : 0360003

    Waratah, New South Wales, 2298, Australia

  • Investigational Site Number : 0560001

    Leuven, 3000, Belgium

  • Investigational Site Number : 0560002

    Woluwe-Saint-Lambert, 1200, Belgium

  • Investigational Site Number : 0560003

    Liège, 4000, Belgium

  • Investigational Site Number : 0560004

    Edegem, B-2650, Belgium

  • Investigational Site Number : 0560005

    Ghent, 9000, Belgium

  • Investigational Site Number : 0560006

    Anderlecht, 1070, Belgium

  • Investigational Site Number : 1000001

    Sofia, 1797, Bulgaria

  • Investigational Site Number : 1000003

    Sofia, 1618, Bulgaria

  • Investigational Site Number : 1000004

    Sofia, 1330, Bulgaria

  • Investigational Site Number : 1000007

    Plovdiv, 4002, Bulgaria

  • Investigational Site Number : 1000008

    Burgas, 8000, Bulgaria

  • Investigational Site Number : 1000010

    Pleven, 5800, Bulgaria

  • Investigational Site Number : 1240003

    Greenfield Park, Quebec, J4V 2H1, Canada

  • Investigational Site Number : 1240010

    Montreal, Quebec, H1T 1P7, Canada

  • Investigational Site Number : 1520001

    Viña del Mar, Valparaiso, 2520598, Chile

  • Investigational Site Number : 1520002

    Santiago, Reg Metropolitana de Santiago, 8420383, Chile

  • Investigational Site Number : 1520006

    Santiago, Reg Metropolitana de Santiago, 7500921, Chile

  • Investigational Site Number : 1520007

    Santiago, Reg Metropolitana de Santiago, 7500713, Chile

  • Investigational Site Number : 1520009

    Santiago, Reg Metropolitana de Santiago, 7650568, Chile

  • Investigational Site Number : 1560001

    Guangzhou, 510080, China

  • Investigational Site Number : 1560005

    Harbin, 150081, China

  • Investigational Site Number : 1560006

    Wuhan, 430079, China

  • Investigational Site Number : 1560009

    Changchun, 130012, China

  • Investigational Site Number : 1560010

    Changchun, 130021, China

  • Investigational Site Number : 1560011

    Hangzhou, 310022, China

  • Investigational Site Number : 1560012

    Nanning, 530021, China

  • Investigational Site Number : 1560015

    Changsha, 410006, China

  • Investigational Site Number : 1560016

    Zhanjiang, 524001, China

  • Investigational Site Number : 1560017

    Guangzhou, 510515, China

  • Investigational Site Number : 1560019

    Nanjing, 210009, China

  • Investigational Site Number : 1560021

    Hangzhou, 310014, China

  • Investigational Site Number : 1560023

    Nanjing, 210006, China

  • Investigational Site Number : 1560024

    Fuzhou, 350008, China

  • Investigational Site Number : 1560025

    Hangzhou, 310003, China

  • Investigational Site Number : 1560026

    Beijing, 100142, China

  • Investigational Site Number : 1560032

    Chengdu, 610041, China

  • Investigational Site Number : 1560033

    Hangzhou, 310009, China

  • Investigational Site Number : 1560036

    Guangzhou, 510095, China

  • Investigational Site Number : 1560037

    Guangzhou, 510163, China

  • Investigational Site Number : 1560038

    Chengdu, 610041, China

  • Investigational Site Number : 1560039

    Changsha, 410011, China

  • Investigational Site Number : 1560040

    Zhengzhou, 450008, China

  • Investigational Site Number : 1560041

    Zhengzhou, 450003, China

  • Investigational Site Number : 1560043

    Chongqing, 400042, China

  • Investigational Site Number : 1560044

    Chongqing, 400038, China

  • Investigational Site Number : 1560045

    Tianjin, 300060, China

  • Investigational Site Number : 1560047

    Jinan, 250013, China

  • Investigational Site Number : 1560050

    Huizhou, 516001, China

  • Investigational Site Number : 2500001

    Marseille, 13015, France

  • Investigational Site Number : 2500002

    Saint-Mandé, 94160, France

  • Investigational Site Number : 2500003

    Rennes, 35033, France

  • Investigational Site Number : 2500004

    Villejuif, 94800, France

  • Investigational Site Number : 2500006

    Créteil, 94010, France

  • Investigational Site Number : 2500007

    Grenoble, 38043, France

  • Investigational Site Number : 2500008

    Caen, 14076, France

  • Investigational Site Number : 2500009

    Pierre-Bénite, 69495, France

  • Investigational Site Number : 2500010

    Bordeaux, 33076, France

  • Investigational Site Number : 2500011

    Paris, 75231, France

  • Investigational Site Number : 2500012

    Saint-Herblain, 44800, France

  • Investigational Site Number : 2500013

    Montpellier, 34295, France

  • Investigational Site Number : 2500014

    Paris, 75970, France

  • Investigational Site Number : 2760001

    Heidelberg, 69126, Germany

  • Investigational Site Number : 2760002

    Essen, 45147, Germany

  • Investigational Site Number : 3000001

    Athens, 11527, Greece

  • Investigational Site Number : 3000003

    Heraklion, 71500, Greece

  • Investigational Site Number : 3000004

    Ioannina, 455 00, Greece

  • Investigational Site Number : 3000005

    Athens, 11526, Greece

  • Investigational Site Number : 3000006

    Thessaloniki, 54645, Greece

  • Investigational Site Number : 3480003

    Budapest, 1121, Hungary

  • Investigational Site Number : 3480005

    Kaposvár, 7400, Hungary

  • Investigational Site Number : 3480007

    Budapest, 1125, Hungary

  • Investigational Site Number : 3760001

    Haifa, 3109601, Israel

  • Investigational Site Number : 3760002

    Kfar Saba, 44281, Israel

  • Investigational Site Number : 3760003

    Petah Tikva, 49100, Israel

  • Investigational Site Number : 3800001

    Milan, 20133, Italy

  • Investigational Site Number : 3800003

    Orbassano, Torino, 10043, Italy

  • Investigational Site Number : 3800004

    Ravenna, Emilia-Romagna, 48121, Italy

  • Investigational Site Number : 3800005

    Rozzano, Milano, 20089, Italy

  • Investigational Site Number : 3800006

    Catania, Italy

  • Investigational Site Number : 3920001

    Hirakata-shi, Osaka, 573-1191, Japan

  • Investigational Site Number : 3920002

    Nagoya, Aichi-ken, 460-0001, Japan

  • Investigational Site Number : 3920003

    Osaka, Osaka, 541-8567, Japan

  • Investigational Site Number : 3920004

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Investigational Site Number : 3920005

    Yokohama, Kanagawa, 241-8515, Japan

  • Investigational Site Number : 3920006

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Investigational Site Number : 3920007

    Wakayama, Wakayama, 641-8510, Japan

  • Investigational Site Number : 3920008

    Kurume-shi, Fukuoka, 830-0011, Japan

  • Investigational Site Number : 3920009

    Natori-shi, Miyagi, 981-1293, Japan

  • Investigational Site Number : 3920010

    Ube-shi, Yamaguchi, 755-0241, Japan

  • Investigational Site Number : 3920011

    Bunkyo-ku, Tokyo, 113-8603, Japan

  • Investigational Site Number : 3920012

    Fukuoka, Fukuoka, 810-8563, Japan

  • Investigational Site Number : 3920013

    Osaka Sayama-shi, Osaka, 589-8511, Japan

  • Investigational Site Number : 3920015

    Nagoya, Aichi-ken, 464-8681, Japan

  • Investigational Site Number : 3920016

    Sapporo, Hokkaido, 003-0804, Japan

  • Investigational Site Number : 3920017

    Himeji-shi, Hyōgo, 670-8520, Japan

  • Investigational Site Number : 3920018

    Mitaka-shi, Tokyo, 181-8611, Japan

  • Investigational Site Number : 4100001

    Seoul, 06591, South Korea

  • Investigational Site Number : 4100003

    Seoul, Seoul-teukbyeolsi, 06351, South Korea

  • Investigational Site Number : 4100004

    Seoul, Seoul-teukbyeolsi, 07061, South Korea

  • Investigational Site Number : 4100005

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Investigational Site Number : 4100006

    Seoul, Seoul-teukbyeolsi, 03722, South Korea

  • Investigational Site Number : 4100007

    Seoul, Seoul-teukbyeolsi, 05505, South Korea

  • Investigational Site Number : 4100008

    Busan, Busan, 48108, South Korea

  • Investigational Site Number : 4840003

    Cuauhtémoc, Mexico City, 06700, Mexico

  • Investigational Site Number : 5280003

    's-Hertogenbosch, 5223 GZ, Netherlands

  • Investigational Site Number : 5280004

    Breda, 4818 CK, Netherlands

  • Investigational Site Number : 5280005

    Utrecht, 3543 AZ, Netherlands

  • Investigational Site Number : 6160001

    Warsaw, 02-781, Poland

  • Investigational Site Number : 6160004

    Olsztyn, Warmian-Masurian Voivodeship, 10-357, Poland

  • Investigational Site Number : 6200001

    Lisbon, 1769, Portugal

  • Investigational Site Number : 6200002

    Almada, 2801-951, Portugal

  • Investigational Site Number : 6200004

    Lisbon, 1998-018, Portugal

  • Investigational Site Number : 6200005

    Porto, 4099-001, Portugal

  • Investigational Site Number : 6200006

    Porto, 4100-180, Portugal

  • Investigational Site Number : 6420003

    Bucaresti, 022328, Romania

  • Investigational Site Number : 6420005

    Timișoara, 300166, Romania

  • Investigational Site Number : 6420008

    Alba Iulia, 510077, Romania

  • Investigational Site Number : 6420009

    Brasov, 500152, Romania

  • Investigational Site Number : 6420010

    Cluj-Napoca, 400124, Romania

  • Investigational Site Number : 6420011

    Cluj-Napoca, 407280, Romania

  • Investigational Site Number : 6420012

    Otopeni, 75100, Romania

  • Investigational Site Number : 6430001

    Moscow, 115478, Russia

  • Investigational Site Number : 6430003

    Saint Petersburg, 197758, Russia

  • Investigational Site Number : 7020001

    Singapore, 308433, Singapore

  • Investigational Site Number : 7020002

    Singapore, 329563, Singapore

  • Investigational Site Number : 7240001

    L'Hospitalet de Llobregat, Barcelona [Barcelona], 08908, Spain

  • Investigational Site Number : 7240002

    Madrid, 28041, Spain

  • Investigational Site Number : 7240004

    Málaga, 29010, Spain

  • Investigational Site Number : 7240005

    Barcelona, Barcelona [Barcelona], 08036, Spain

  • Investigational Site Number : 7240006

    Pamplona, Navarre, 31008, Spain

  • Investigational Site Number : 7240007

    Barcelona, Barcelona [Barcelona], 08028, Spain

  • Investigational Site Number : 7240008

    Valencia, 46026, Spain

  • Investigational Site Number : 7240009

    Madrid / Madrid, Madrid, Comunidad de, 28040, Spain

  • Investigational Site Number : 7240011

    Seville, 41013, Spain

  • Investigational Site Number : 7920001

    Istanbul, 34303, Turkey (Türkiye)

  • Investigational Site Number : 7920002

    Adana, 01250, Turkey (Türkiye)

  • Investigational Site Number : 7920005

    Istanbul, 34214, Turkey (Türkiye)

  • Investigational Site Number : 7920006

    Istanbul, 34722, Turkey (Türkiye)

  • Investigational Site Number : 7920007

    Izmir, Turkey (Türkiye)

  • Investigational Site Number : 7920008

    Adana, 01060, Turkey (Türkiye)

  • Investigational Site Number : 7920009

    Malatya, Turkey (Türkiye)

  • Investigational Site Number : 7920010

    Izmir, Turkey (Türkiye)

  • Investigational Site Number : 7920011

    Ankara, 06800, Turkey (Türkiye)

  • Investigational Site Number : 7920012

    Adana, 01140, Turkey (Türkiye)

  • Investigational Site Number : 7920014

    Kocaeli, 41100, Turkey (Türkiye)

  • Lankenau Hospital Cancer Center- Site Number : 8400017

    Wynnewood, Pennsylvania, 19096-3411, United States

  • Medical College of Wisconsin- Site Number : 8400006

    Milwaukee, Wisconsin, 53226, United States

  • Renovatio Clinical - Site Number : 8400013

    The Woodlands, Texas, 77380, United States

  • Renovatio Clinical- Site Number : 8400032

    El Paso, Texas, 79915, United States

  • Roswell Park Cancer Institute Site Number : 8400011

    Buffalo, New York, 14263-0001, United States

  • ~Instituto De Oncologia Parana- Site Number : 0760008

    Curitiba, Paraná, 80530-010, Brazil

Conditions

Explore the condition pages connected to this study.