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New imaging methods aim to spare healthy lung during cancer radiation

NCT ID NCT06159660

Knowledge-focused Sponsor: University of Sydney Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether special X-ray imaging techniques can map which parts of the lung are working best, so radiation for lung cancer can avoid those areas. Fifteen adults with stage II-IV lung cancer will get extra scans before and after their standard radiation treatment. The goal is to see if these imaging methods are accurate enough to guide safer radiation plans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to more precise radiation planning that avoids damaging healthy lung tissue, potentially reducing side effects for future patients.
What could go wrong
This is a very small, early observational study (15 people) that is testing imaging methods, not a treatment. The techniques may not prove accurate enough or practical for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients having non-SABR radiotherapy for stage II-IV lung cancer at Northern Sydney Cancer Centre, Sydney Australia.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 years or older. * Eastern Cooperative Oncology Group (ECOG) performance status 0-2. * Histologically proven Stage II-IV non-small cell lung cancer as determined using the IASLC International Association for the Study of Lung Cancer (IASLC) 8th edition lung cancer staging guidelines. * To be treated with curative intent (stage II-III) or palliative intent (stage IV) with non-SABR external beam radiotherapy (e.g. 60 Gy in 30 treatments for curative intent or 30 Gy in 5 treatments for palliative intent). * Pulmonary function tests within 8 weeks of registration. * 4DCT simulation for radiation therapy. * Willingness to give written informed consent. * Willingness and ability to comply with the study procedures and visit requirements. * Available for follow up for 1 year or until death, whichever occurs first. Exclusion Criteria: * Prior radiation therapy to the thorax. * Prior surgery for this cancer. * Prior chemotherapy for this cancer. * Interstitial lung disease. * Pregnant women.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung neoplasm

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal North Shore Hospital

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

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