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New pill shows promise in early trial for tough blood cancers

NCT ID NCT04139434

First seen Jan 27, 2026 · Last updated May 21, 2026 · Updated 21 times

Summary

This early-phase study tested an experimental pill called LP-108, taken alone or with another drug (azacitidine), in 32 adults with blood cancers (MDS, CMML, or AML) that returned or didn't respond to prior therapy. The main goals were to find the safest dose and understand how the drug moves through the body. Researchers also looked for signs that the cancer shrank or disappeared.

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Contacts and locations

Locations

  • Hospital San Pedro de Alcántara

    Cáceres, Cáceres, 10003, Spain

  • Institut Català d'oncologia - ICO Badalona

    Badalona, Barcelona, 08916, Spain

  • Instituto de Investigación Sanitaria La Fe

    Valencia, Valencia, CP 46026, Spain

  • MD Anderson Cancer Center

    Huston, Texas, 77030, United States

  • Ohio State Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45221, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

Conditions

Explore the condition pages connected to this study.