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Less radiation may work just as well for some lymphoma patients

NCT ID NCT03681535

First seen Nov 01, 2025 · Last updated Jun 10, 2026 · Updated 34 times

Summary

This study looks at whether giving a lower dose of radiation (20 Gy instead of 30 Gy) to a smaller area can still keep lymphoma from coming back in patients who had a clear PET scan after chemotherapy. About 241 adults with diffuse large B-cell lymphoma are taking part. The goal is to maintain high local control while reducing side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital

    Weymouth, Massachusetts, 02190, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Juntendo University

    Tokyo, Japan

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • National Cancer Center of Singapore

    Singapore, Singapore

  • University Hospital Motol

    Prague, Czechia

  • University of Rochester James P. Wilmot Cancer Institute

    Rochester, New York, 14642, United States

  • University of Torino

    Torino, Italy

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yonsei University Health System

    Seoul, South Korea

Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.