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Light weights, big gains: study shows lifting to failure works wonders

NCT ID NCT07412600

Knowledge-focused Sponsor: Akdeniz University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether lifting light weights (30% of your max) until you can't do another rep builds muscle and strength as well as lifting heavy weights (75% of your max) in healthy young men who don't usually lift. Twenty-two men did leg exercises three times a week for six weeks. The results showed both groups got similar increases in muscle size and strength, suggesting that pushing to failure matters more than how much you lift.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Started

Dec 2021

Finished

Jul 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 28 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male sex * Age between 18 and 28 years * Healthy status as determined by self-report health screening * No participation in structured resistance training or lower-limb power training within the previous 12 months * Engaging only in recreational physical activity (no systematic lower-body resistance training) * Willingness to maintain usual daily routines throughout the study period * Agreement to refrain from any structured lower-body resistance training during the 6-week intervention * Provision of written informed consent Exclusion Criteria: * Any current or recent musculoskeletal injury affecting lower-limb function * History or presence of cardiovascular disease * History or presence of metabolic disorders * Resting hypertension (≥140/90 mmHg) * Regular tobacco use * Use of medications known to affect neuromuscular performance * Inability or unwillingness to comply with the training protocol

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Conditions

The condition(s) this trial relates to.

myostatin-related muscle hypertrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Muscle hypertrophy Resistance training

Contacts and locations

Locations

  • Selcuk University

    Meram, Konya, 04204, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.