Can sound waves soothe pain? new study probes Brain's response
NCT ID NCT06343883
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This study is testing how different pressure levels of low-intensity focused ultrasound (LIFU) affect brain activity related to pain. Researchers will use EEG and fMRI to measure brain responses in 25 healthy adults before and after ultrasound. The goal is to understand how LIFU might influence pain processing, not to treat pain directly.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- low-intensity focused ultrasound (device)
- What this could lead to
- If successful, this could help researchers understand how ultrasound might be used to manage pain in the future.
- What could go wrong
- This is a very early, small study (25 people) focused on measuring brain activity, not treating pain. It may not lead to any direct treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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1 person
The number who actually took part.
- Started
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Oct 2024
- Finished
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Oct 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Understand and speak English Exclusion Criteria: 1. Claustrophobia (scanning environment may be uncomfortable). 2. Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 3. Contraindications to CT: pregnancy 4. Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) 5. History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor) 6. History of head injury resulting in loss of consciousness for \>10 minutes. 7. History of alcohol or drug dependence (through self-report).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fralin Biomedical Research Institute at VTC
Roanoke, Virginia, 24016, United States
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