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Dietary twist: Low-Histamine mediterranean plan shows promise for MS fatigue

NCT ID NCT07501520

Symptom relief Sponsor: Firat University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tested whether a low-histamine version of the Mediterranean diet could help people with relapsing-remitting multiple sclerosis (MS) feel better. 51 adults were split into three groups: one followed the low-histamine Mediterranean diet, another a standard Mediterranean diet, and a third made no diet changes. Researchers measured fatigue, disability, and other symptoms, along with blood markers of inflammation and oxidative stress, to see if lowering dietary histamine adds extra benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

51 people

The number who actually took part.

Started

Jun 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 19 to 64 years. * Diagnosis of relapsing-remitting multiple sclerosis (RRMS) according to 2017 McDonald criteria. * EDSS score \< 4.5. * On stable immunomodulatory treatment for at least 6 months. * Body mass index (BMI) 18.5-24.9 kg/m². Exclusion Criteria: * Relapse and/or corticosteroid treatment within the last 1 month. * Clinically significant metabolic, progressive, or malignant disease. * Use of at least 1 g/day fish oil supplementation. * Insulin-dependent diabetes mellitus. * Participation in another interventional study. * Weight loss or gain ≥ 5% in the last 6 months. * Following a weight-loss diet in the last 2 months. * Use of oral anticoagulant therapy. * Presence of eating disorders, alcohol or substance dependence. * Pregnancy or breastfeeding. * Inability to comply with dietary intervention according to weekly follow-up assessments.

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Conditions

The condition(s) this trial relates to.

Fatigue relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mediterranean diet Multiple sclerosis (MS) - relapsing-remitting

Contacts and locations

Locations

  • Firat University Hospital, Neurology Clinic

    Elâzığ, Elâzığ, 23119, Turkey (Türkiye)

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