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ICU recovery mystery: could metabolism hold the key?

NCT ID NCT07170527

Knowledge-focused Sponsor: ARH van Zanten, MD PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This study follows 200 ICU survivors for 12 months to understand why some recover well while others struggle, even if they were healthy before. Researchers will measure metabolic changes during critical illness and track physical function, muscle strength, and body composition over time. The goal is to identify patterns that could lead to better support for recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors predict which ICU patients will struggle with recovery and point toward new ways to improve physical function after critical illness.
What could go wrong
This is an early, observational study that does not test any treatment. It may not find clear links between metabolism and recovery, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of 200 adult patients admitted to the ICU of Gelderse Vallei Hospital, Ede, with an expected ICU length of stay of ≥72 hours, or who receive invasive mechanical ventilation (IMV) or non-invasive ventilation (NIV) within 48 hours after ICU admission and are expected to receive this ventilatory support (IMV or NIV) for ≥48 hours.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years at time of ICU admission; * Received ventilatory support (IMV or NIV) within 48 hours after ICU admission with an expected duration of ≥48 hours during ICU stay (irrespective of ICU length of stay); OR * An expected ICU length of stay of ≥72 hours (irrespective of ventilatory support). Exclusion Criteria: * Concurrent participation in an intervention study with an anticipated therapeutic effect on PICS outcomes (physical functioning, cognitive functioning, or mental health status) * Pre-admission diagnosis of a progressive neurological disease (e.g., Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, progressive forms of multiple sclerosis) * Participants with neurological paralysis significantly affecting leg function (e.g., spinal cord injury, multiple sclerosis) * Patients receiving palliative care, with a life expectancy of \<3 months (e.g., hospice care or equivalent) * Patients who are moribund (i.e., in the final stages of a terminal illness, with imminent death expected) * Anticipated logistical limitations during recovery phase (e.g., transfer to another hospital, no fixed abode); * Deemed not suitable to participate based upon the judgement of the treating intensivist.

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Conditions

The condition(s) this trial relates to.

Critical Illness postintensive care syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-intensive care syndrome (PICS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Gelderse Vallei Hospital

    RECRUITING

    Ede, Gelderland, 6716 RP, Netherlands

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