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Tiny study tests At-Home workout for long COVID fatigue in veterans

NCT ID NCT05699538

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether a once-a-week home-based resistance exercise program could help reduce fatigue in veterans aged 50 and older with Long COVID. The study enrolled 21 participants and measured changes in muscle strength and perceived tiredness. The goal was to understand the causes of fatigue and see if this minimal exercise approach is safe and feasible.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
minimal-dose home-based resistance exercise
What this could lead to
If it works, this could point toward a simple, at-home exercise program to help reduce fatigue in older veterans with Long COVID.
What could go wrong
This is a very small, early feasibility study with only 21 participants. Results may not apply to all Long COVID patients, and the exercise program may not be effective for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Jul 2023

Finished

Sep 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ambulatory patients (with or without a gait aid) * 50 years of age or older * with a confirmed diagnosis of COVID-19 by polymerase chain reaction (PCR) test, antibody test or clinical diagnosis * the symptom of fatigue reported greater than 12-weeks post-infection (reporting fatigue: yes/no) * receiving care at the DC VAMC * the ability to speak and read English, and orientation to person, place, and time * the comparison group will include ambulatory patients (with or without a gait aid) * 50 years of age or older * with a confirmed diagnosis of COVID-19 by PCR test, antibody test or clinical diagnosis * without the symptom of fatigue reported greater than 12-weeks post-infection * receiving care at the DC VAMC * the ability to speak and read English, and orientation to person, place, and time Exclusion Criteria: * \<50 years of age without a confirmed diagnosis of COVID-19 by PCR test * antibody test or clinical diagnosis or with a confirmed diagnosis of COVID-19 of \<12-weeks * non-ambulatory individuals * Veterans who do not use the DC VAMC as their main site for care * body mass index 40 kg/m2 * diagnosis of psychiatric disorder(s) * any medically uncontrolled cardiovascular * musculoskeletal disease, or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

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Conditions

The condition(s) this trial relates to.

COVID-19 Fatigue long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Long COVID

Contacts and locations

Locations

  • Washington DC VA Medical Center, Washington, DC

    Washington D.C., District of Columbia, 20422-0001, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.