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EDS Patients' numbing shots put to the test

NCT ID NCT04036305

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares how people with Ehlers-Danlos syndrome (EDS) and healthy volunteers respond to local anesthetics like lidocaine and bupivacaine. Researchers inject a small amount under the skin and measure pain sensation at different times. The goal is to find out if reported numbing resistance is real and whether it fades too quickly.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lidocaine, Bupivacaine, and Saline (as control)
What this could lead to
If successful, this could help doctors understand why some EDS patients feel pain even after numbing injections, leading to better pain management strategies.
What could go wrong
This is an observational study, not a treatment trial. It only measures pain response in a small injection test, so results may not apply to all EDS patients or real-world procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 230 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

EDS patients and non-EDS participants

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * EDS patients, clinically diagnosed hypermobile EDS based on 2017 criteria * EDS patients with genetically proven non-hypermobile EDS * Healthy participants, no EDS * Able and willing to provide informed consent Exclusion Criteria: * Known allergy to Lidocaine or Bupivacaine * Unable to provide informed consent

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Conditions

The condition(s) this trial relates to.

Ehlers-Danlos syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia, local Ehlers-Danlos syndrome

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.