EDS Patients' numbing shots put to the test

NCT ID NCT04036305

Ongoing Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares how people with Ehlers-Danlos syndrome (EDS) and healthy volunteers respond to local anesthetics like lidocaine and bupivacaine. Researchers inject a small amount under the skin and measure pain sensation at different times. The goal is to find out if reported numbing resistance is real and whether it fades too quickly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lidocaine, Bupivacaine, and Saline (as control)
What this could lead to: If successful, this could help doctors understand why some EDS patients feel pain even after numbing injections, leading to better pain management strategies.
What could go wrong: This is an observational study, not a treatment trial. It only measures pain response in a small injection test, so results may not apply to all EDS patients or real-world procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ehlers-Danlos syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA, LOCAL EHLERS-DANLOS SYNDROME

Contacts and locations

Locations

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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