EDS Patients' numbing shots put to the test
NCT ID NCT04036305
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares how people with Ehlers-Danlos syndrome (EDS) and healthy volunteers respond to local anesthetics like lidocaine and bupivacaine. Researchers inject a small amount under the skin and measure pain sensation at different times. The goal is to find out if reported numbing resistance is real and whether it fades too quickly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lidocaine, Bupivacaine, and Saline (as control)
What this could lead to
If successful, this could help doctors understand why some EDS patients feel pain even after numbing injections, leading to better pain management strategies.
What could go wrong
This is an observational study, not a treatment trial. It only measures pain response in a small injection test, so results may not apply to all EDS patients or real-world procedures.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States