Pinprick test: does injecting numbing medicine into different skin layers change how long it works?
NCT ID NCT07724418
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether injecting local anesthetic into different layers of the skin on the forearm changes how long the numbing effect lasts. Healthy adults receive a small injection of lidocaine with epinephrine either just under the skin or into the skin itself. Researchers measure the time from when numbness begins to when sharp sensation returns.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- lidocaine with epinephrine
- What this could lead to
- If it works, this could help doctors choose the best injection depth for numbing during skin procedures.
- What could go wrong
- This is a small, early-phase study in healthy volunteers on the forearm, not on the face or other surgical sites, so results may not apply directly to real procedures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Aug 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female ≥ 18 years of age * Normal skin sensation at both nasal ala and volar forearms assessed by pinprick * Ability to provide informed consent Exclusion Criteria: * Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated * Pregnant or breastfeeding volunteers (assessed by self-report) * Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for This study will focus on in-office dermatological procedures are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Weill Cornell Medicine
New York, New York, 10065, United States